Researcher
Marlies Vanden Bempt
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Systems biology
Affiliations
- Laboratory of Experimental Hematology (Division)
Member
From1 Feb 2020 → 31 Jan 2021 - Cools Lab (Research group)
Member
From1 Jan 2017 → Today - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From15 Sep 2013 → Today
Projects
1 - 7 of 7
- Molecular characterization of hyperactive T cell receptor signaling in peripheral T cell lymphoma to uncover druggable targetsFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular characterization of genetic events driving development of peripheral T cell lymphomaFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular characterization of genetic events driving development of peripheral T cell lymphomaFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Single-molecule multi-omics to study tumour heterogeneity and evolutionFrom1 Sep 2022 → TodayFunding: Foundations, funds and other with scientific goal
- Cooperation between N-MYC overexpression and epiginetic deregulation in peripheral T cell lymphomaFrom1 Oct 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Extensive preclinical validation of combinations of targeted treatment for peripheral T cell lymphomaFrom10 Aug 2021 → 30 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Study Of Cooperating Oncogenes In The Development Of T-Cell Acute Lymphoblastic Leukemia Using CRISPR/Cas-Generated Cell And Mouse Models.From15 Sep 2013 → 31 Dec 2018Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
Publications
1 - 10 of 12
- Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma(2022)
Authors: Marlies Vanden Bempt, Koen Debackere, Sofie Demeyer, Quentin Van Thillo, Nienke Meeuws, David Nittner, Thomas Tousseyn, Jan Cools, Daan Dierickx
Pages: 2463 - 2476 - Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified(2021)
Authors: Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Gregor Verhoef, Lucienne Michaux, Thomas Tousseyn, Jan Cools, Daan Dierickx
- A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer(2021)
Authors: Ayse Bassez, Hanne Vos, Laurien Van Dyck, Beppe Floris, Ingrid Arijs, Christine Desmedt, Bram Boeckx, Marlies Vanden Bempt, Ines Nevelsteen, Kathleen Lambein, et al.
Pages: 820 - + - Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia(2019)
Authors: Michaël Broux, Cristina PRIETO FERNANDEZ, Sofie Demeyer, Marlies Vanden Bempt, Inge Lodewijckx, Jan Cools
Pages: 1323 - 1336 - Oncogene mechanismen van fusiegenen in hematologische aandoeningen(2018)
Authors: Marlies Vanden Bempt, Jan Cools
- Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia(2018)
Authors: Marlies Vanden Bempt, Sofie Demeyer, Michaël Broux, Jolien De Bie, Simon Bornschein, Ellen Geerdens, Charles De Bock, Jan Cools
Pages: 271 - + - EML1–ABL1 Is Activated by Coiled-Coil-Mediated Oligomerization and Induces T-Cell Acute Lymphoblastic Leukemia or Myeloproliferative Disease in a Mouse Bone Marrow Transplant Model(2018)
Authors: Kim De Keersmaecker, Marlies Vanden Bempt, Peter Vandenberghe, Jan Cools
- HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development(2018)
Authors: Charles De Bock, Sofie Demeyer, Sandrine Degryse, Delphine Verbeke, Marlies Vanden Bempt, Ellen Geerdens, Simon Bornschein, Rik Gijsbers, Jan Cools
Pages: 616 - 631 - Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL(2018)
Authors: Sandrine Degryse, Simon Bornschein, Charles De Bock, Marlies Vanden Bempt, Sofie Demeyer, Ellen Geerdens, Jan Cools
Pages: 421 - 425 - ALK-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene(2017)
Authors: Jo-Anne van de Krogt, Marlies Vanden Bempt, Julio Finalet Ferreiro, Nicole Mentens, Kris Jacobs, Ursula Pluys, Kathleen Doms, Ellen Geerdens, Anne Uyttebroeck, Pascal Pierre, et al.
Pages: 1605 - 1616