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Researcher
Mieke Dewerchin
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Cardiac and vascular medicine
- See also: Mieke Dewerchin (Flanders Institute for Biotechnology)
Affiliations
- Carmeliet Lab (Research group)
Member
From1 Jan 2017 → Today - Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven) (Division)
Member
From1 Jan 2012 → Today - Centre for Molecular and Vascular Biology (Division)
Member
From1 Oct 1999 → 30 Sep 2005
Projects
1 - 10 of 16
- Endothelial immunosuppressive mystery genes in spleen for alternative immunotherapy: dissecting their features via lipid nanoparticle-based target validationFrom10 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysisFrom1 May 2018 → 30 Apr 2022Funding: FWO Medium Size Research Infrastructure
- Meningeal cells contribute to cortical neurogenesis in postnatal brainFrom13 Apr 2015 → 15 Mar 2016Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of the pyruvate kinase isoforms PKM1 and PKM2 in endothelial cell metabolism and angiogenesisFrom1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- The serine synthesis pathway: an unexplored metabolic pathway in endothelial cells, regulating angiogenesis?From1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- Understanding the metabolism of lymphatic endothelial cells.From1 Oct 2014 → 27 Feb 2017Funding: FWO fellowships
- The role of PFKFB3 in tumor angiogenesis and vessel normalizationFrom1 Sep 2014 → 18 Apr 2017Funding: Own budget, for example: patrimony, inscription fees, gifts
- Endothelial glutamine metabolism : target for anti-tumor angiogenesis therapy.From1 Jan 2013 → 31 Dec 2017Funding: Private funding of national origin - undefined
- Glycosylatie van angiogene factoren via de hexosamine biosyntheseweg, een nutriënten-sensor met een functie in metabole signalering in angiogenese?From1 Sep 2012 → 18 Oct 2016Funding: FWO fellowships
- Investigating the role of endothelial glutamine metabolism in the control of angiogenesis.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 118
- COVID-19 plasma induces subcellular remodelling within the pulmonary microvascular endothelium.(2024)
Authors: Mieke Dewerchin
Pages: 107277 - How Does Temporal and Sequential Delivery of Multiple Growth Factors Affect Vascularization Inside 3D Hydrogels?(2024)
Authors: Mieke Dewerchin
- Detailed protocol for a corneal thermal cauterization-based (lymph-)angiogenesis assay in mice(2023)
Authors: Anh-Co Truong, Koen Veys, Mieke Dewerchin, Peter Carmeliet
- Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells(2023)
Authors: Flore Sneyers, Martijn Kerkhofs, Rita La Rovere, Mieke Dewerchin, Bart Ghesquière, Geert Bultynck
- VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway(2023)
Authors: Mieke Dewerchin, Peter Carmeliet
- Covid-19 Plasma Exposure Causes Transcriptional, Morphological, And Functional Changes Within The Pulmonary Microvascular Endothelium(2023)
Authors: Mieke Dewerchin
- Prioritization and functional validation of target genes from single-cell transcriptomics studies(2023)
Authors: Anh-Co Truong, Mieke Dewerchin, Peter Carmeliet
- The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution(2023)
Authors: Bram Boeckx, Sander Jansen, Simon Feys, Stijn Verleden, Laurens Liesenborghs, Sébastien Dumas, Mila Borri, Liliana Sokol, Anh-Co Truong, Jan Gunst, et al.
Pages: 520 - 535 - A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds(2023)
Authors: Mieke Dewerchin, Peter Carmeliet
Pages: 680 - 692 - Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells(2022)
Authors: Mieke Dewerchin, Peter Carmeliet