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- Research interest:Use of the zebrafish model (embryo, larva, adult) for fundamental and applied research. Understanding the mechanisms underlying toxicity, including endocrine disruption, by integrating responses at the molecular, biochemical and physiological level both in the context of ecotoxicology and human toxicology. European regulation related to hazard and risk evaluation of chemicals, including endocrine disrupting chemicals. Statistical analysis and biological interpretation of omics datasets. Development of alternative testing strategies using in vitro and zebrafish embryo assays based on the 3R principle. Development and use of adverse outcome pathways (AOPs) according to official OECD guidelines and procedures. Laboratory animal regulation and animal welfare.
- Keywords:ANIMAL WELFARE, PREDICITVE TOXICOLOGY, TOXICOLOGY, ADVERSE OUTCOME PATHWAY, ZEBRAFISH, ENDOCRINE DISRUPTION, ECOTOXICOLOGY, TOXICOGENOMICS, Biomedical sciences (incl. biochemistry)
- Disciplines:Ecotoxicology, Environmental impact and risk assessment, Environmental health and safety, Toxicogenomics, Developmental biology
- Research techniques:Zebrafish embryo test, adverse outcome pathway, zebrafish exposure experiment, gene expression analysis, zebrafish behaviour analysis, enzyme inhibition assay, energy metabolism analysis, passive dosing
- Users of research expertise:industry, regulators