Researcher
Lode Wyns
- Research Expertise:
- Fundamental Research in Eukaryotic Gene Expression. Protein Structure and Action (X-ray crystallography). Protein engineering (Site directed mutagenesis/Enzym kinetics).
- Keywords:General and logistic services, Applied biological sciences, biotechnology
- Disciplines:Biomedical image processing, General and logistic services
- Users of research expertise:
- Fundamental Research in Eukaryotic Gene Expression. Protein Structure and Action (X-ray crystallography). Protein engineering (Site directed mutagenesis/Enzym kinetics).
Affiliations
- Vriendenkring VUB (Office)
Member
From1 Oct 2012 → Today - Department of Bio-engineering Sciences (Department)
Member
From1 Oct 2012 → 30 Sep 2013 - Department of General Biology (Research group)
Member
From22 Jul 2008 → 31 Jul 2008 - Structural Biology Brussels (Department)
Member
From18 Dec 2003 → 30 Sep 2012 - Ultrastructure (Research group)
Member
From31 Dec 1999 → 1 Jan 2010 - Department of Bio-engineering Sciences (Department)
Member
From1 Jun 1996 → 30 Sep 2013 - FORMER_Structural Biology Brussels (Research group)
Member
From1 Jan 1990 → 30 Sep 2012 - Department of General Biology (Research group)
Member
From1 Oct 1979 → 30 Sep 1991
Projects
1 - 8 of 8
- Design, synthesis, and in vivo evaluation of carbohydrate-based anti-adhesins against UTls caused by E.coli.From1 Apr 2010 → 31 Mar 2013Funding: FWO research project (including WEAVE projects)
- PA14 carbohydrate-binding domains from yeast adhesive proteins: biophysical characterisation and engineering towards clinical applications.From1 Jan 2010 → 31 Dec 2013Funding: IWT personal funding - strategic basic research grants
- Structural biology of Helicobacter pylori virulence factorsFrom1 Jan 2009 → 31 Dec 2013Funding: FWO Odysseus
- The influence of antibody fragments on the micro fibrilogenese of beta 2-globulin.From1 Jan 2009 → 31 Dec 2012Funding: IWT personal funding - specialisation scholarships
- 3D4Health : Protection structures for health: Structural biology of therapeutic membrane proteins as a starting point for effective rational drug design.From1 Jun 2008 → 31 May 2011Funding: Brussels Capital Region
- Proteins: Structure en Folding.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
- The engineering of new adhesins based on If-proteins from Candida albicans and Flo-proteins from Saccharomyces cerevisiae.From1 Jan 2008 → 31 Dec 2011Funding: IWT personal funding - specialisation scholarships
- Flemish Interuniversity project for structural studies of hard and soft condensed matter with synchrotron radiation.From1 Jan 2008 → 31 Dec 2012Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 27
- Study of the structural and dynamic effects in the FimH adhesin upon α-D-heptyl mannose binding(2014)
Authors: Sophie Vanwetswinkel, A.N. Volkov, Yann G.J. Sterckx, Abel Garcia-Pino, Lieven Buts, Wim Vranken, Julie Bouckaert, Rene Roy, Lode Wyns, Nico van Nuland
Pages: 1416-1427 - Validation of reactivity descriptors to assess the aromatic stacking within the tyrosine gate of FimH(2013)
Authors: Goedele Roos, Adinda Wellens, Mohamed Touaibia, Nao Yamakawa, Paul Geerlings, Rene Roy, Lode Wyns, Julie Bouckaert
Pages: 1085-1090 - A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.(2013)
Authors: Erwin De Genst, Ph Chan, Els Pardon, Shang-Te Danny Hsu, Janet Kumita, John Christodoulou, Linda Menzer, Chirgadze Dimitri, Carol V. Robinson, Serge Muyldermans, et al.
Pages: 13245-13258 - Nanobodies Raised against Monomeric alpha-Synuclein Distinguish between Fibrils at Different Maturation Stages(2013)
Authors: Tim Guilliams, Farah El-Turk, Alexander K. Buell, Elizabeth M. O'day, Francesco A. Aprile, Elin K. Esbjoerner, Michele Vendruscolo, Nunilo Cremades, Els Pardon, Lode Wyns, et al.
Pages: 2397-2411 - Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta 2-microglobulin variant(2011)
Authors: Katarzyna Domanska, Saskia Vanderhaegen, Vasundara Srinivasan, Els Pardon, Florine Dupeux, Jose A. Marquez, Sofia Giorgetti, Monica Stoppini, Lode Wyns, Vittorio Bellotti, et al.
Pages: 1314-1319 - Structure and Properties of a Complex of alpha-Synuclein and a Single-Domain Camelid Antibody(2010)
Authors: Erwin De Genst, Tim Guilliams, Joke Wellens, Elizabeth M. O'day, Christopher A. Waudby, Sarah Meehan, Mireille Dumoulin, Shang-Te Danny Hsu, Nunilo Cremades, Koen Verschueren, et al.
Pages: 326-343 - Allostery and intrinsic disorder mediate transcription regulation by conditional co-operativity(2010)
Authors: Abel Garcia-Pino, Sreeram Balasubramanian, Lode Wyns, Ehud Gazit, Henri De Greve, Roy Magnuson, Daniel Charlier, Nico van Nuland, Remy Loris
Pages: 101-111 - How thioredoxin dissociates its mixed disulfide(2009)
Authors: Goedele Roos, Nicolas Foloppe, Koen Van Laer, Lode Wyns, Lennart Nilsson, Paul Geerlings, Joris Messens
Pages: 1000461 - Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.(2009)
Authors: E. Ordóñez, Karolien Van Belle, Goedele Roos, Sandra De Galan, M. Letek, J. A. Gil, Lode Wyns, L.m. Mateos, Joris Messens
Pages: 15107-15116 - Coupling of domain swapping to kinetic stability in a thioredoxin mutant.(2009)
Authors: Abel Garcia-Pino, Sergio Martinez Rodriguez, Khadija Wahni, Lode Wyns, Remy Loris, Joris Messens
Pages: 1590-1599
Patents
1 - 2 of 2
- Epitope tag for affinity-based applications (Inventor)
- Epitope tag for affinity-based applications (Inventor)