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Researcher
Lieve Naesens
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 15
- Inhibition of lung inflammation in pneumonia induced by micro-organismsFrom1 Mar 2023 → TodayFunding: IOF - technology validation in lab
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Designing airway-targeted prodrug strategies for anti-respiratory virus therapeuticsFrom12 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Hitting coronavirus replication in its core by combined inhibition of the nsp12 polymerase and associated proteins of the replication-transcription complexFrom13 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Covalent locking of the influenza virus hemagglutinin prefusion structure: an innovative concept to create broadly protective influenza vaccinesFrom7 Sep 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Entry inhibitors for human respiratory virus SARS-CoV-2.From21 Aug 2017 → 6 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Automated real-time quantitative live cell analysisFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Characterization of the influenza virus polymerase using T-705 and ribavirin and design of RNA chain terminating prodrugs of these unique antiviral agentsFrom1 Jan 2015 → 31 Dec 2017Funding: FWO research grant KAN
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
Publications
41 - 50 of 179
- Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors(2019)
Authors: Evelien Vanderlinden, Lieve Naesens
- Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives(2019)
Authors: Lieve Naesens
Pages: 1533 - 1544 - Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir)(2019)
Authors: Evelien Vanderlinden, Lieve Naesens
Pages: 1 - 5 - Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro[4.5]decan-3-one derivatives(2019)
Authors: Annelies Stevaert, Lieve Naesens
- Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway(2019)
Authors: Pieter Vrijens, Sam Noppen, Els Vanstreels, Manon Laporte, Sandra Liekens, Annelies Stevaert, Lieve Naesens
Pages: 583 - 601 - Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase(2018)
Authors: Lieve Naesens
Pages: 10 - 22 - Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents(2018)
Authors: Annelies Stevaert, Evelien Vanderlinden, Lieve Naesens
Pages: 1017 - 1030 - Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening(2018)
Authors: Lily Karamanou, Annelies Stevaert, Lieve Naesens
Pages: 4544 - 4550 - Prodrugs of the Phosphoribosylated Forms of Hydroxypyrazinecarboxamide Pseudobase T-705 and Its De-Fluoro Analogue T-1105 as Potent Influenza Virus Inhibitors(2018)
Authors: Evelien Vanderlinden, Lieve Naesens
Pages: 6193 - 6210 - Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)(2018)
Authors: Lieve Naesens
Pages: 229 - 243