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Researcher
Lieve Naesens
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 15
- Inhibition of lung inflammation in pneumonia induced by micro-organismsFrom1 Mar 2023 → TodayFunding: IOF - technology validation in lab
- Development of modified anhydrohexitol nucleic acid (HNA) and altritol nucleic acid (ANA) antisense oligonucleotides to combat SARS-CoV-2From21 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dual targeting of nsp12 and nsp15: a powerful concept to suppress coronavirus replication and transcriptionFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- Designing airway-targeted prodrug strategies for anti-respiratory virus therapeuticsFrom12 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Hitting coronavirus replication in its core by combined inhibition of the nsp12 polymerase and associated proteins of the replication-transcription complexFrom13 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Covalent locking of the influenza virus hemagglutinin prefusion structure: an innovative concept to create broadly protective influenza vaccinesFrom7 Sep 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Entry inhibitors for human respiratory virus SARS-CoV-2.From21 Aug 2017 → 6 Jun 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Automated real-time quantitative live cell analysisFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Characterization of the influenza virus polymerase using T-705 and ribavirin and design of RNA chain terminating prodrugs of these unique antiviral agentsFrom1 Jan 2015 → 31 Dec 2017Funding: FWO research grant KAN
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
Publications
151 - 160 of 179
- Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy(2010)
Authors: Lieve Naesens
Pages: 165 - 9 - Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents(2010)
Authors: Graciela Andrei, Lieve Naesens, Johan Neyts, Erik De Clercq, Jan Balzarini, Robert Snoeck
Pages: 6825 - 37 - Alkoxy-5-nitrosopyrimidines: useful building block for the generation of biologically active compounds(2010)
Authors: Lieve Naesens, Erik De Clercq
Pages: 3823 - 30 - Conservation of HHV-6 DNA polymerase processivity factor sequence and predicted structure suggests it as a target for antiviral development(2010)
Authors: Lieve Naesens
Pages: 316 - 9 - Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii(2010)
Authors: Alain Meli Lannang, Gabin Nselapi Louh, Bernadette Messi Biloa, Justin Komguem, Celine Djama Mbazoa, Beiban Luc Sondengam, Lieve Naesens, Christophe Pannecouque, Erik De Clercq, El H Sayed El Ashry
Pages: 708 - 12 - Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity(2010)
Authors: Lieve Naesens
Pages: 2713 - 7 - Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin(2010)
Authors: Evelien Vanderlinden, Mathy Froeyen, Lieve Naesens
Pages: 4277 - 88 - Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii(2010)
Authors: Lieve Naesens, Christophe Pannecouque, Erik De Clercq
Pages: 708 - 12 - Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin(2010)
Authors: Lieve Naesens, Johan Neyts, Jan Balzarini
Pages: 2748 - 2755 - Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study(2009)
Authors: Lieve Naesens
Pages: 6053 - 6061