Researcher
Leonie Wyffels
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Molecular Imaging and Radiology (MIRA) (Research group)
Member
From1 Jan 2019 → 30 Sep 2019 - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Feb 2012 → 31 Dec 2018
Projects
1 - 7 of 7
- Development of novel TCO probes for pretargeted intracellular PET imaging.From1 Oct 2018 → 31 Oct 2019Funding: BOF - Other initiatives
- Development of novel cell death PET imaging probes for early treatment response assessment.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Development of a caspase-3 selective activity-based probe for PET imaging of apoptosisFrom1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Development of 18F-poly(2-oxazoline)-duramycin and 18Fpoly( 2-oxazoline)-RGD as radiotracers for in vivo imaging of tumor environment.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Poxylation as next generation Pegylation.From1 Feb 2013 → 31 Jan 2014Funding: SBO (Strategic basic research)
- PET and SPECT imaging of protease activity by activitybased probes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Immuno-positron emission tomography as a potential biomarker for diagnosis and treatment in Alzheimer disease.From1 Apr 2012 → 31 Mar 2014Funding: IWT / VLAIO - indirect funding by business world
Publications
61 - 70 of 73
- Characterization of $^{99m}Tc$-labeled cytokine ligands for inflammation imaging via TNF and IL-1 pathways(2012)
Authors: Zhonglin Liu, Leonie Wyffels, Christy Barber, Li Wan, Hua Xu, Mizhou M. Hui, Lars R. Furenlid, James M. Woolfenden
Pages: 905 - 915 - Antiepileptic drugs modulate P-glycoproteins in the brain(2011)
Authors: Lieselotte Moerman, Leonie Wyffels, Dominique Slaets, Robrecht Raedt, Paul Boon, Filip De Vos
Pages: 18 - 25 - A $^{99m}Tc$-labeled dual-domain cytokine ligand for imaging of inflammation(2011)
Authors: Zhonglin Liu, Leonie Wyffels, Christie Barber, Mizhou M. Hui, James M. Woolfenden
Pages: 795 - 805 - Synthesis and preliminary evaluation of radiolabeled bis(zinc(II)dipicolylamine) coordination complexes as cell death imaging agents(2011)
Authors: Leonie Wyffels, Brian D. Gray, Christy Barber, James M. Woolfenden, Koon Y. Pak, Zhonglin Liu
Pages: 3425 - 3433 - Radiosynthesis and in vivo evaluation of $[^{11}C]$-labelled pyrrole-2-carboxamide derivates as novel radioligands for PET imaging of monoamine oxidase A(2010)
Authors: Sylvie de Bruyne, Giuseppe La Regina, Steven Staelens, Leonie Wyffels, Steven Deleye, Romano Silvestri, Filip de Vos
Pages: 459 - 467 - PET imaging of fatty acid amide hydrolase in the brain(2010)
Authors: Leonie Wyffels, Giulio G. Muccioli, Coco N. Kapanda, Geoffray Labar, Sylvie De Bruyne, Filip De Vos, Didier M. Lambert
Pages: 665 - 675 - Radiosynthesis and in vivo evaluation of $[^{11}C]MC80$ for P-glycoprotein imaging(2010)
Authors: Sylvie De Bruyne, Leonie Wyffels, Lieselotte Moerman, Johan Sambre, Nicola A. Colabufo, Francesco Berardi, Roberto Perrone, Filip De Vos
Pages: 6489 - 6495 - In vivo evaluation of $[^{123}I]$-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine, an iodinated SPECT tracer for imaging the P-gp transporter(2010)
Authors: Sylvie de Bruyne, Leonie Wyffels, Terence L. Boos, Steven Staelens, Steven Deleye, Kenner C. Rice, Filip de Vos
Pages: 469 - 477 - Synthesis, radiosynthesis and in vivo evaluation of $[^{123}I]$-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter(2009)
Authors: S. De Bruyne, T.L. Boos, Leonie Wyffels, J.L. Goeman, K.C. Rice, F. De Vos
Pages: 304 - 311 - Effect of cyclosporin A administration on the biodistribution and multipinhole $\mu$SPECT imaging of $[^{123}I]$R91150 in rodent brain(2009)
Authors: P. Blanckaert, I. Burvenich, Steven Staelens, S. de Bruyne, L. Moerman, Leonie Wyffels, F. de Vos
Pages: 446 - 453