Researcher
Koen Raemdonck
- Disciplines:Nanobiotechnology, Environmental safety and health of nanotechnology, Nanoscale characterisation, Nanophotonics, Nanotechnology not elsewhere classified, Nanometrology, Drug discovery and development not elsewhere classified, Clinical trials, Other pharmaceutical sciences not elsewhere classified, Compound screening, In vitro testing, Biopharmaceuticals, Non-clinical studies, Molecular medicine, Vaccines, Nanomaterials, Nanomanufacturing, Nanofabrication, growth and self assembly, Nanoelectromechanical systems
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2004 → Today
Infrastructure
1 - 1 of 1
- Confocal and two-photon Microscope (Consortium partner)
Projects
1 - 10 of 18
- Exploring co-encapsulation of antihistamines and immune checkpoint siRNAs in lipid nanoparticles for cancer immunotherapy.From1 Oct 2023 → TodayFunding: BOF - doctoral mandates
- Conformationally locked G4-decoy oligonucleotides for selective telomerase inhibition and development of a nucleic acid-based anti-telomerase PROTAC strategyFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Synthesis of modified PNA probes for sequence-selective G-quadruplex photoalkylation.From1 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- REpurposing lung Surfactant Protein B for Inhalation therapy with RNA therapeuticsFrom1 May 2021 → TodayFunding: H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
- Repurposing lung surfactant protein B for inhalation therapy with RNA therapeuticsFrom1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Stimulated emission depletion microscopy (STED): Nanoscopy for innovative research in the life sciencesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- NANOMED / Colloidally stable nanogel formulations for siRNA deliveryFrom1 Aug 2019 → 31 Jan 2020Funding: BOF - doctoral mandates
- Local immunomodulation of atherosclerosis by CD8+ T-cell based nanomedicinesFrom1 May 2019 → 30 Apr 2022Funding: FWO research project (including WEAVE projects)
- RNA-MAGIC: RNA-based bioMArkers and tarGets In asthma and Chronic Obstructive Pulmonary Disease (COPD)From1 Jan 2019 → TodayFunding: BOF - projects
- Combination cancer therapy by simultaneous delivery of cationic amphiphilic drugs and RNA therapeutics using a polymer delivery platformFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
21 - 30 of 87
- Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner(2020)
Authors: Thijs Van de Vyver, Bram Bogaert, Lynn De Backer, Freya Joris, Roberta Guagliardo, Jelter Van Hoeck, Pieterjan Merckx, Srinivas Ramishetti, Dan Peer, Katrien Remaut, et al.
Pages: 4774 - 4791 - Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation(2020)
Authors: Laurens Raes, Stephan Stremersch, Juan Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, et al.
- Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA(2019)
Authors: Roberta Guagliardo, Pieterjan Merckx, Agata Zamborlin, Lynn De Backer, Mercedes Echaide, Jesus Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
- Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells(2019)
Authors: Lien Van Hoecke, Laurens Raes, Stephan Stremersch, Toon Brans, Juan Fraire, Ria Roelandt, Wim Declercq, Peter Vandenabeele, Koen Raemdonck, Kevin Braeckmans, et al.
- Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells(2019)
Authors: Laurens Raes, Clarissa Van Hecke, Julie Michiels, Stephan Stremersch, Juan Fraire, Toon Brans, Ranhua Xiong, Stefaan De Smedt, Linos Vandekerckhove, Koen Raemdonck, et al.
- Challenges for labeling and longitudinal tracking of adoptively transferred autoreactive T lymphocytes in an experimental type-1 diabetes model(2019)
Authors: Shweta Saini, Hannelie Korf, Sayuan Liang, Rein Verbeke, Bella Manshian, Koen Raemdonck, Ine Lentacker, Conny Gysemans, Uwe Himmelreich
Pages: 295 - 305 - Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate(2019)
Authors: Juan Fraire, Stephan Stremersch, Davinia Bouckaert, Tinne Monteyne, Thomas De Beer, Pieter Wuytens, Andre Skirtach, Koen Raemdonck, Kevin Braeckmans
Pages: 39424 - 39435 - Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy(2018)
Authors: Pieterjan Merckx, Lynn De Backer, Lien Van Hoecke, Roberta Guagliardo, Mercedes Echaide, Pieter Baatsen, Bárbara Olmeda, Jésus Pérez-Gil, Koen Raemdonck
Pages: 236 - 246 - Nucleic acid loading and fluorescent labeling of isolated extracellular vesicles requires adequate purification(2018)
Authors: Stephan Stremersch, Toon Brans, Kevin Braeckmans, Koen Raemdonck
Pages: 783 - 792 - Pulmonary surfactant and drug delivery : focusing on the role of surfactant proteins(2018)
Authors: Roberta Guagliardo, Jésus Pérez-Gil, Koen Raemdonck
Pages: 116 - 126
Patents
1 - 7 of 7
- MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- Method and system for characterizing extracellular vesicles (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)
- MOLECULAR ADJUVANTS FOR ENHANCED CYTOSOLIC DELIVERY OF ACTIVE AGENTS (Inventor)
- PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS (Inventor)