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Researcher
Kian Koh
- Disciplines:Developmental biology, Epigenetics, Stem cell biology
Affiliations
- Stem Cell and Developmental Biology (Division)
Member
From1 Apr 2013 → Today - Department of Development and Regeneration (Department)
Member
From1 Oct 2012 → 31 Mar 2013
Projects
1 - 10 of 15
- Lineage-specific epigenetic regulation by TET1 in the pre-streak mouse embryoFrom1 Jan 2023 → TodayFunding: FWO fellowships
- Next-generation, multi-technology immune-monitoring and easy-access spectral flow cytometryFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- The early embryonic function of TET DNA dioxygenases in human neurulation and disease.From1 Oct 2021 → TodayFunding: BOF - projects
- The contribution of TET proteins during global DNA demethylation in epigenetic reprogramming and pluripotency inductionFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The contribution of TET DNA dioxygenases during global DNA demethylation in epigenetic reprogramming and pluripotency induction.From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The IncuCyte S3/Organoid platform for live cell culture imaging and kinetic multiparameter analysis of state-of-the-art 3D organoid models and complex tissue mimicsFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- The interplay of TET1, DNA methylation and vitamin metabolism in neurulation.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Epigenetic interactions of DNA oxygenase TET1 in neural tube closure.From1 Oct 2018 → 1 Oct 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- Lineage-specific epigenetic regulation by DNA oxygenase TET1 in the pre-streak mouse embryoFrom1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- Closing the neural tube: gene-gene interactions of TET1 and the interplay with nutrient metabolismFrom1 Jan 2018 → 9 Nov 2023Funding: FWO fellowships
Publications
11 - 20 of 20
- Dynamics of Tet1 and Oct4 gene activation identify temporally distinct late stages in reprogramming of induced pluripotency.(2019)
Authors: Michela Bartoccetti, Kian Koh, Catherine Verfaillie
- Lineage-specific functions of TET1 in the postimplantation mouse embryo(2017)
Authors: Rita Khoueiry, Bernard Thienpont, Xinlong Luo, Michela Bartoccetti, Bram Boeckx, An Zwijsen, Diether Lambrechts, Kian Koh
Pages: 1061 - + - PDGFR alpha(+) Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors(2017)
Authors: Antonio Lo Nigro, Anchel de Jaime Soguero, Rita Khoueiry, Ilaria Perini, Kian Koh, An Zwijsen, Frederic Lluis Vinas, Catherine Verfaillie
Pages: 318 - 333 - Tumour hypoxia causes DNA hypermethylation by reducing TET activity(2016)
Authors: Bernard Thienpont, Hui Zhao, Flora D'Anna, Bart Ghesquière, Laurien Van Dyck, Bram Boeckx, Frédéric Amant, Kian Koh, Max Mazzone, Peter Carmeliet, et al.
Pages: 63 - 68 - Dynamic Switching of Active Promoter and Enhancer Domains Regulates Tet1 and Tet2 Expression during Cell State Transitions between Pluripotency and Differentiation(2015)
Authors: Michela Bartoccetti, Rita Khoueiry, Lien Spans, Linde De Troyer, Frank Claessens, Kian Koh
Pages: 1026 - 1042 - Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX(2013)
Authors: Kian Koh
Pages: 122 - 6 - DNA methylation and methylcytosine oxidation in cell fate decisions(2013)
Authors: Kian Koh
Pages: 152 - 61 - Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2(2010)
Authors: Kian Koh
Pages: 839 - 843 - Domain Requirements and Sequence Specificity of DNA Binding for the Forkhead Transcription Factor FOXP3(2009)
Authors: Kian Koh
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1(2009)
Authors: Kian Koh
Pages: 930 - 935