Researcher
Karolien De Bosscher
- Keywords (Ghent University):cellular signal transduction, nuclear receptors
- Disciplines (Flanders Institute for Biotechnology):Analytical biochemistry, Cell death and senescence, Analysis of next-generation sequence data, General diagnostics
- Disciplines (Ghent University):Nucleic acids, Other organic elements and compounds, Proteins, Regulation of metabolism, Cell signalling, Transcription and translation, Endocrinology and metabolic diseases not elsewhere classified, Cell death, Cancer biology, Medical biochemistry and metabolism not elsewhere classified, Animal cell and molecular biology, Carbohydrates, Energy metabolism, Inorganic elements and compounds, Lipids
Affiliations
- De Bosscher Lab (Research group)
Responsible
From1 Jan 2019 → Today - Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Tavernier Lab (Research group)
Member
From1 Jan 2017 → 31 Dec 2018 - Department of Biochemistry (Department)
Member
From7 Oct 2010 → 30 Sep 2018 - Department of Physiology (Department)
Member
From1 Jan 2009 → 6 Oct 2010 - Department of Biomedical molecular biology (Department)
Member
From1 Oct 1995 → 31 Dec 2008
Projects
11 - 20 of 20
- Glucocorticoid receptor-centered heterodimer formation under physiological and pathophysiological conditionsFrom1 Oct 2021 → TodayFunding: BOF - projects
- The study of the therapeutic potential of PPARa-ERRa ligand combinations in non-alcoholic fatty liver diseaseFrom1 Nov 2020 → TodayFunding: FWO fellowships
- In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scan.From1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Characterization of the PPARα-ERRα interaction and crosstalk in non-alcoholic fatty liver diseaseFrom1 Oct 2019 → 20 Feb 2022Funding: BOF - postdoctoral mandates
- Combining lower doses of glucocorticoids with mineralocorticoid receptor antagonists as a novel drug repurposing strategy in multiple myelomaFrom1 Oct 2018 → 31 Dec 2021Funding: Foundations, funds and other with scientific goal
- Exploration of HDAC6 inhibitors as anti-inflammatory agents – linking HDAC6 chemistry with inflammation biologyFrom1 Oct 2017 → 30 Sep 2021Funding: BOF - Doctoral projects
- Impact of the nutritional status on the transcriptional cross-talk between PPARalpha and GRalpha in healthy versus inflamed primary hepatocytes.From1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Exploiting novel GR biology as an opportunity to develop safer anti-inflammatory drugsFrom15 Aug 2014 → 31 Mar 2018Funding: IOF - Industrial Research Fund
- Nuclear receptor-based molecular mechanisms in the fight against inflammation and cancerFrom1 Oct 2013 → 31 Jul 2018Funding: BOF - Research professorship
- Study of the transcriptional cross-talk between PPARalfa and ERRalfaFrom1 Mar 2013 → 31 Dec 2017Funding: BOF - Doctoral projects
Publications
1 - 10 of 36
- The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs(2023)
Authors: Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D'hooghe
Pages: 7698 - 7729 - The biologist’s guide to the glucocorticoid receptor’s structure(2023)
Authors: Nick Deploey, Laura Van Moortel, Inez Rogatsky, Frank Peelman, Karolien De Bosscher
- Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding(2022)
Authors: Steven Timmermans, Nicolette J.D. Verhoog, Kelly Van Looveren, Sylviane Dewaele, Tino Hochepied, Melanie Eggermont, Barbara Gilbert, Anne Boerema-de Munck, Tineke Vanderhaeghen, Joke Vanden Berghe, et al.
- Hepatic glucocorticoid‐induced transcriptional regulation is androgen‐dependent after chronic but not acute glucocorticoid exposure(2022)
Authors: Jacobus C. Buurstede, Susana N. Paul, Karolien De Bosscher, Onno C. Meijer, Jan Kroon
- The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma(2022)
Authors: Silke Geurs, Dorien Clarisse, Eleni Staessens, Karolien De Bosscher, Matthias D'hooghe
Number of pages: 1 - Regulatory role of the intestinal microbiota in the immune response against Giardia(2021)
Authors: Brecht Maertens, Aurélie Gagnaire, Oonagh Paerewijck, Karolien De Bosscher, Peter Geldhof
- Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium(2020)
Authors: Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, et al.
- Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system(2020)
Authors: Kelly Van Looveren, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Marlies Ballegeer, Jolien Souffriau, Melanie Eggermont, Jolien Vandewalle, Lise Van Wyngene, Karolien De Bosscher, et al.
- Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies(2020)
Authors: Dorien Clarisse, Fritz Offner, Karolien De Bosscher
- TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile(2019)
Authors: Karen Dendoncker, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Joanna Lempiäinen, Ville Paakinaho, Evelien Van Hamme, Sylviane Dewaele, Sofie Vandevyver, Marlies Ballegeer, et al.
Pages: 12942 - 12951