Researcher
Karolien De Bosscher
- Keywords (Ghent University):cellular signal transduction, nuclear receptors
- Disciplines (Flanders Institute for Biotechnology):Analytical biochemistry, Cell death and senescence, Analysis of next-generation sequence data, General diagnostics
- Disciplines (Ghent University):Nucleic acids, Other organic elements and compounds, Proteins, Regulation of metabolism, Cell signalling, Transcription and translation, Endocrinology and metabolic diseases not elsewhere classified, Cell death, Cancer biology, Medical biochemistry and metabolism not elsewhere classified, Animal cell and molecular biology, Carbohydrates, Energy metabolism, Inorganic elements and compounds, Lipids
Affiliations
- De Bosscher Lab (Research group)
Responsible
From1 Jan 2019 → Today - Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Tavernier Lab (Research group)
Member
From1 Jan 2017 → 31 Dec 2018 - Department of Biochemistry (Department)
Member
From7 Oct 2010 → 30 Sep 2018 - Department of Physiology (Department)
Member
From1 Jan 2009 → 6 Oct 2010 - Department of Biomedical molecular biology (Department)
Member
From1 Oct 1995 → 31 Dec 2008
Projects
1 - 10 of 20
- Disentangling the complexity and diversity of glucocorticoid receptor signalingFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammationFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scanFrom1 Nov 2023 → TodayFunding: BOF - doctoral mandates
- Study of novel bivalent ligands targeting glucocorticoid and mineralocorticoid receptor heterodimers: towards an improved glucocorticoid-based multiple myeloma therapy"From1 Nov 2023 → TodayFunding: Nonprofit institution or equivalents
- Integrative interactome and protein modification analysis of HNF4α in sepsisFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseasesFrom1 Oct 2023 → TodayFunding: BOF - projects
- The Best Of Both Worlds: Nuclear Receptor Heterodimers To Battle Against Rheumatoid Arthritis.From1 Oct 2022 → 31 Dec 2023Funding: FWO junior postdoctoral fellowship
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- STOP_SEPSIS: investigation into a new concept of sepsis, the greatest unmet medical need of our times.From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
Publications
11 - 20 of 36
- Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice(2019)
Authors: Oonagh Paerewijck, Brecht Maertens, Aurélie Gagnaire, Karolien De Bosscher, Peter Geldhof
- Mechanisms underlying the functional cooperation between PPARα and GRα to attenuate inflammatory responses(2019)
Authors: Nadia Bougarne, Viacheslav Mylka, Dariusz Ratman, Ilse Beck, Jonathan Thommis, Lode De Cauwer, Jan Tavernier, Bart Staels, Claude Libert, Karolien De Bosscher
- Adrenal hormones mediate disease tolerance in malaria(2018)
Authors: Leen Vandermosten, Thao-Thy Pham, Sofie Knoops, Charlotte De Geest, Natacha Lays, Kristof Van der Molen, Christopher J Kenyon, Manu Verma, Karen E Chapman, Frans Schuit, et al.
- Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march(2018)
Authors: Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, et al.
Pages: 1360 - 1370 - The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages(2018)
Authors: Viacheslav Mylka, Julie Deckers, Dariusz Ratman, Lode De Cauwer, Jonathan Thommis, Riet De Rycke, Francis Impens, Claude Libert, Jan Tavernier, Wim Vanden Berghe, et al.
Pages: 2049 - 2064 - Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads(2017)
Authors: Chandra S Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus WC Verbeek, Oksana Ryabtsova, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, et al.
- Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells(2017)
Authors: Julie Deckers, Dorine Sichien, Maud Plantinga, Justine Van Moorleghem, Manon Vanheerswynghels, Esther Hoste, Bernard Malissen, David Dombrowicz, Martin Guilliams, Karolien De Bosscher, et al.
Pages: 1364 - 1377.e2 - Unraveling the role of IL-17A in the intestinal immune response against the protozoan parasite Giardia muris by an RNA sequencing approach(2016)
Authors: Oonagh Paerewijck, Leentje Dreesen, Frederik Van Meulder, Dariusz Ratman, Karolien De Bosscher, RW Li, Peter Geldhof
Pages: 14 - 15 - GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A(2016)
Authors: Andres E Barcala Tabarrozzi, Luz Andreone, Julie Deckers, Carla N Castro, María L Gimeno, Laura Ariolfo, Paula M Berguer, María Antunica-Noguerol, Ana C Liberman, Sabine Vettorazzi, et al.
- The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice(2014)
Authors: Michal Pawlak, Eric Baugé, William Bourguet, Karolien De Bosscher, Fanny Lalloyer, Anne Tailleux, Corinna Lebherz, Philippe Lefebvre, Bart Staels
Pages: 1593 - 1606