Researcher
Karolien De Bosscher
- Disciplines (Flanders Institute for Biotechnology):Analytical biochemistry, Cell death and senescence, Analysis of next-generation sequence data, General diagnostics
- Disciplines (Ghent University):Medical biochemistry and metabolism not elsewhere classified, Animal cell and molecular biology, Cell signalling, Carbohydrates, Proteins, Energy metabolism, Inorganic elements and compounds, Regulation of metabolism, Nucleic acids, Lipids, Other organic elements and compounds
Affiliations
- De Bosscher Lab (Research group)
Responsible
From1 Jan 2021 → Today - De Bosscher Lab (Research group)
Member
From1 Jan 2019 → 31 Dec 2020 - Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Tavernier Lab (Research group)
Member
From1 Jan 2017 → 31 Dec 2018 - Department of Biochemistry (Department)
Member
From7 Oct 2010 → 30 Sep 2018 - Department of Physiology (Department)
Member
From1 Jan 2009 → 6 Oct 2010 - Department of Biomedical molecular biology (Department)
Member
From1 Oct 1995 → 31 Dec 2008
Projects
1 - 10 of 32
- Market oriented validation of bivalent ligands: towards an improved treatment for multiple myelomaFrom1 Feb 2023 → Today
- The Best Of Both Worlds: Nuclear Receptor Heterodimers To Battle Against Rheumatoid Arthritis.From1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Glucocorticoid receptor-centered heterodimer formation under physiological and pathophysiological conditionsFrom1 Oct 2021 → TodayFunding: BOF - projects
- STOP_SEPSIS: investigation into a new concept of sepsis, the
greatest unmet medical need of our times.From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- A study of the therapeutic potential of PPARa-ERRa ligand combinations in non-alcoholic fatty liver diseaseFrom1 Jan 2021 → TodayFunding: FWO research project
- The study of the therapeutic potential of PPARa-ERRa ligand combinations in non-alcoholic fatty liver diseaseFrom1 Nov 2020 → TodayFunding: FWO fellowships
- In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scan.From1 Nov 2019 → TodayFunding: FWO Strategic Basic Research Grant
- Characterization of the PPARα-ERRα interaction and crosstalk in non-alcoholic fatty liver diseaseFrom1 Oct 2019 → 20 Feb 2022Funding: BOF - postdoctoral mandates
Publications
1 - 10 of 126
- Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation(2022)
Authors: Silke Geurs, Dorien Clarisse, Freya Baele, Jorick Franceus, Tom Desmet, Karolien De Bosscher, Matthias D'hooghe
Pages: 6239 - 6242 - Hepatic glucocorticoid‐induced transcriptional regulation is androgen‐dependent after chronic but not acute glucocorticoid exposure(2022)
Authors: Jacobus C. Buurstede, Susana N. Paul, Karolien De Bosscher, Onno C. Meijer, Jan Kroon
- Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets(2022)
Authors: Laura Van Moortel, Jonathan Thommis, Brecht Maertens, An Staes, Dorien Clarisse, Delphine De Sutter, Claude Libert, Onno C. Meijer, Sven Eyckerman, Kris Gevaert, et al.
- Reprogramming of glucocorticoid receptor function by hypoxia(2022)
Authors: Tineke Vanderhaeghen, Steven Timmermans, Deepika Watts, Ville Paakinaho, Melanie Eggermont, Jolien Vandewalle, Charlotte Wallaeys, Lise Van Wyngene, Kelly Van Looveren, Louise Nuyttens, et al.
- Approaches towards tissueU+2010selective pharmacology of the mineralocorticoid receptor(2022)
Authors: Dorien Clarisse, Lisa Deng, Karolien De Bosscher, Achim Lother
Pages: 3235 - 3249 - Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding(2022)
Authors: Steven Timmermans, Nicolette J.D. Verhoog, Kelly Van Looveren, Sylviane Dewaele, Tino Hochepied, Melanie Eggermont, Barbara Gilbert, Anne Boerema-de Munck, Tineke Vanderhaeghen, Joke Vanden Berghe, et al.
- Carboxylic acid bioisosteres in medicinal chemistry : synthesis and properties(2022)
Authors: Kato Bredael, Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D'hooghe
- The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma(2022)
Authors: Silke Geurs, Dorien Clarisse, Eleni Staessens, Karolien De Bosscher, Matthias D'hooghe
Number of pages: 1 - How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer(2021)
Authors: Dorien Clarisse, Karolien De Bosscher
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(2021)
Authors: Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, et al.
Pages: 1 - 382