Researcher
Joost Schymkowitz
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Proteins, Bioinformatics of disease, Structural bioinformatics and computational proteomics, Synthetic biology, Proteomics
- See also: Joost Schymkowitz (Flanders Institute for Biotechnology)
Affiliations
- Switch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Switch Laboratory (VIB-KU Leuven) (Division)
Member
From1 Jan 2011 → Today - Department of Cellular and Molecular Medicine (Department)
Member
From15 Sep 2010 → 31 Dec 2010
Infrastructure
1 - 1 of 1
- When size matters: a platform to study molecular interactions and multimerisation (Consortium coordinator)
Projects
1 - 10 of 54
- The Hidden Biology of Inclusion BodiesFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- New molecular tools for diagnostic and treatment of systemic amyloidosisFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural and morphological studies of heterotypic amyloid fibrilsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Heterotypic aggregation of Aβ42 with disease-relevant proteins in Alzheimer’s diseaseFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Cotranslational protein folding and aggregationFrom4 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigation of Heterotypic Interactions of TDP-43 Aggregation in NeurodegenerationFrom11 Apr 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Characterization of novel antibiotics against bacterial protein secretion.From1 Apr 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Convergence of tau and TDP-43 in Alzheimer's: towards a multitarget diagnosisFrom1 Dec 2021 → 31 Oct 2022Funding: BOF - postdoctoral mandates
- Rational design of biologics for therapeutic development (FoldCo)From19 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 158
- Heterotypic interactions in amyloid diseases(2022)
Authors: Katerina Konstantoulea, Frederic Rousseau, Nikolaos Louros, Joost Schymkowitz
- Exploiting Ligand-binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors(2022)
Authors: Christine Helsen, Tien Nguyen, Xiao Yin Lee, Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau, Frank Claessens, Arnout Voet
Pages: 1823 - 1834 - De novo missense variants in the E3 ubiquitin ligase adaptor KLHL20 cause a developmental disorder with intellectual disability, epilepsy, and autism spectrum disorder(2022)
Authors: Yoeri Sleyp, Patrick Callaerts, Jarymke Maljaars, Frederic Rousseau, Joost Schymkowitz, Erika Souche, Jean Steyaert, Hilde Peeters
Pages: 2464 - 2474 - Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease(2022)
Authors: Nikolaos Louros, Katerina Konstantoulea, Frederic Rousseau, Joost Schymkowitz
Pages: 123 - 131 - Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer's disease(2022)
Authors: Tessa Robberechts, Marta Koper, Joost Schymkowitz, Frederic Rousseau, Dietmar Thal
Pages: 3558 - 3570 - Impact of heat and enzymatic treatment on ovalbumin amyloid-like fibril formation and enzyme-induced gelation(2022)
Authors: Lomme Deleu, Joëlle Housmans, Jan Delcour, Frederic Rousseau, Joost Schymkowitz
- Investigating the Sequence Determinants of the Curling of Amyloid Fibrils Using Ovalbumin as a Case Study(2022)
Authors: Joëlle Housmans, Bert Houben, Grigoria Tsaka, Nikolaos Louros, Sebastien Carpentier, Jan Delcour, Frederic Rousseau, Joost Schymkowitz
Pages: 3779 - 3797 - Thermodynamic analysis of amyloid fibril structures reveals a common framework for stability in amyloid polymorphs(2022)
Authors: Rob van der Kant, Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
Pages: 1178 - + - The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis(2022)
Authors: Rob van der Kant, Frederic Rousseau, Joost Schymkowitz
- Bioavailability and Health Impact of Ingested Amyloid-like Protein Fibrils and their Link with Inflammatory Status: A Need for More Research?(2022)
Authors: Jan Delcour, Frederic Rousseau, Joost Schymkowitz
Patents
1 - 10 of 10
- Molecules targeting ras protein (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Beta-lactamase inhibitors (Inventor)
- Carbon dioxide generation (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Means and methods for the prediction of amyloid core sequences (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting ras protein (Inventor)
- Carbon dioxide generation (Inventor)