Researcher
Joost Schymkowitz
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Proteins, Bioinformatics of disease, Structural bioinformatics and computational proteomics, Synthetic biology, Proteomics
- See also: Joost Schymkowitz (Flanders Institute for Biotechnology)
Affiliations
- Switch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Switch Laboratory (VIB-KU Leuven) (Division)
Member
From1 Jan 2011 → Today - Department of Cellular and Molecular Medicine (Department)
Member
From15 Sep 2010 → 31 Dec 2010
Infrastructure
1 - 1 of 1
- When size matters: a platform to study molecular interactions and multimerisation (Consortium coordinator)
Projects
1 - 10 of 54
- The Hidden Biology of Inclusion BodiesFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- New molecular tools for diagnostic and treatment of systemic amyloidosisFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Heterotypic aggregation of Aβ42 with disease-relevant proteins in Alzheimer’s diseaseFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Structural and morphological studies of heterotypic amyloid fibrilsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Cotranslational protein folding and aggregationFrom4 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigation of Heterotypic Interactions of TDP-43 Aggregation in NeurodegenerationFrom11 Apr 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Characterization of novel antibiotics against bacterial protein secretion.From1 Apr 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Convergence of tau and TDP-43 in Alzheimer's: towards a multitarget diagnosisFrom1 Dec 2021 → 31 Oct 2022Funding: BOF - postdoctoral mandates
- Rational design of biologics for therapeutic development (FoldCo)From19 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
101 - 110 of 159
- Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions(2017)
Authors: Sarah Veugelen, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Bart De Strooper, Lucia Chavez Gutierrez
Pages: 443 - 456 - Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodeling by p53 aggregation(2017)
Authors: Frederik De Smet, Mirian Saiz Rubio, Daphne Hompes, Evelyne Naus, Tobias Langenberg, Bert Houben, Filip Claes, Stéphane Plaisance, Frédéric Amant, Xavier Sagaert, et al.
Pages: 24 - 38 - Prediction and Reduction of the Aggregation of Monoclonal Antibodies(2017)
Authors: Rob van der Kant, Jim Van Durme, Rodrigo Gallardo, Ann Gils, Joost Schymkowitz, Frederic Rousseau
Pages: 1244 - 1261 - Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics(2017)
Authors: Steven Boeynaems, Elke Bogaert, Mathias De Decker, Thomas Vercruysse, Dirk Daelemans, Joost Schymkowitz, Frederic Rousseau, Wim Robberecht, Philip Van Damme, Ludo Van Den Bosch
Pages: 1044 - 1055 - De novo design of a biologically active amyloid(2016)
Authors: Rodrigo Gallardo, Frederik De Smet, Filip Claes, Laleh Khodaparast, Ladan Khodaparast, Tobias Langenberg, Maxime Siemons, Manoj Kumar Gautam, Manu Beerens, Aernout Luttun, et al.
- Loss of function mutations in dipeptidyl peptidase 6 in Alzheimer disease and Frontotemporal dementia: a novel pathway in neurodegeneration(2016)
Authors: R Cacace, T Van den Bossche, J Lippiat, J Janssens, G De Baets, S Engelborghs, A Sieben, M Vandenbulcke, P de Rijk, E Cuyvers, et al.
Pages: 231 - 232 - Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling (vol 23, pg 489, 2013)(2016)
Authors: Corentin Herbert, Ulrich Schieborr, Krishna Saxena, Jarek Juraszek, Frederik De Smet, Chantal Alcouffe, Marc Bianciotto, Giorgio Saladino, David Sibrac, Denis Kudlinzki, et al.
Pages: 176 - 178 - Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling(2016)
Authors: Rodrigo Gallardo, Rudra Shankar Kashyap, Joost Schymkowitz, Frederic Rousseau, Pascale Zimmermann
- Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool(2016)
Authors: Arunkumar Tharkeshwar Raghunath, Roger Habets, Rosanne Wouters, Sebastian Munck, Rita Derua, Etienne Waelkens, Mathieu Bollen, Joost Schymkowitz, Frederic Rousseau, Bart De Strooper, et al.
Pages: 193 - 208 - Sequence-specific protein aggregation generates defined protein knockdowns in plants(2016)
Authors: Rodrigo Gallardo, Frederik De Smet, Frederic Rousseau, Joost Schymkowitz
Pages: 773 - 787
Patents
1 - 10 of 10
- Molecules targeting ras protein (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Beta-lactamase inhibitors (Inventor)
- Carbon dioxide generation (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Means and methods for the prediction of amyloid core sequences (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting ras protein (Inventor)
- Carbon dioxide generation (Inventor)