Researcher
Joost Schymkowitz
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Proteins, Bioinformatics of disease, Structural bioinformatics and computational proteomics, Synthetic biology, Proteomics
- See also: Joost Schymkowitz (Flanders Institute for Biotechnology)
Affiliations
- Switch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Switch Laboratory (VIB-KU Leuven) (Division)
Member
From1 Jan 2011 → Today - Department of Cellular and Molecular Medicine (Department)
Member
From15 Sep 2010 → 31 Dec 2010
Infrastructure
1 - 1 of 1
- When size matters: a platform to study molecular interactions and multimerisation (Consortium coordinator)
Projects
1 - 10 of 54
- The Hidden Biology of Inclusion BodiesFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- New molecular tools for diagnostic and treatment of systemic amyloidosisFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural and morphological studies of heterotypic amyloid fibrilsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Heterotypic aggregation of Aβ42 with disease-relevant proteins in Alzheimer’s diseaseFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Cotranslational protein folding and aggregationFrom4 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigation of Heterotypic Interactions of TDP-43 Aggregation in NeurodegenerationFrom11 Apr 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Characterization of novel antibiotics against bacterial protein secretion.From1 Apr 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Convergence of tau and TDP-43 in Alzheimer's: towards a multitarget diagnosisFrom1 Dec 2021 → 31 Oct 2022Funding: BOF - postdoctoral mandates
- Rational design of biologics for therapeutic development (FoldCo)From19 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 159
- SNPeffect 5.0: large-scale structural phenotyping of protein coding variants extracted from next-generation sequencing data using AlphaFold models(2023)
Authors: Frederic Rousseau, Joost Schymkowitz
- Targeted aggregation as a therapeutic strategy in cancer(2023)
Authors: Kobe Janssen, Frederic Rousseau, Joost Schymkowitz
- Reverse engineering synthetic antiviral amyloids (vol 11, 2832, 2020)(2023)
Authors: Emiel Michiels, Rodrigo Gallardo, Laleh Khodaparast, Ladan Khodaparast, Rob van der Kant, Bert Houben, Nikolaos Louros, Suzanne Kaptein, Guy Bormans, Johan Neyts, et al.
- Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation(2023)
Authors: Nikolaos Louros, Laleh Khodaparast, Ladan Khodaparast, Frederic Rousseau, Joost Schymkowitz
- EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation(2023)
Authors: Marianna Decet, Lily Karamanou, Nikolaos Louros, Tassos Economou, Frederic Rousseau, Joost Schymkowitz, Patrik Verstreken
Pages: 1402 - + - Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship(2023)
Authors: Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rodrigo Gallardo, Frederic Rousseau, Joost Schymkowitz
- Sodium glutamate and glutamic acid decarboxylase as alternative for classical chemical leavening in wheat (pan)cake batter systems(2023)
Authors: Thibault Godefroidt, Rob van der Kant, Elien Lemmens, Lomme Deleu, Kurt Gebruers, Joost Schymkowitz, Frederic Rousseau, Jan Delcour
- Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation(2023)
Authors: Filip Claes, Rob van der Kant, Mark Fiers, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
- Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein(2023)
Authors: Kobe Janssen, Filip Claes, Bert Houben, Mieke Nys, Laleh Khodaparast, Ladan Khodaparast, Nikolaos Louros, Rob van der Kant, Katerina Konstantoulea, Joost Schymkowitz, et al.
- Food-borne amyloids: analysis, engineering and design(2023)
Authors: Joëlle Housmans, Joost Schymkowitz, Frederic Rousseau
Patents
1 - 10 of 10
- Molecules targeting ras protein (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Beta-lactamase inhibitors (Inventor)
- Carbon dioxide generation (Inventor)
- Molecules targeting mutant ras protein (Inventor)
- Means and methods for the prediction of amyloid core sequences (Inventor)
- Molecules targeting proteins (Inventor)
- Molecules targeting ras protein (Inventor)
- Carbon dioxide generation (Inventor)