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Researcher
Johan Swinnen
- Disciplines:Oncology, Medical systems biology
Affiliations
- Laboratory of Lipid Metabolism and Cancer (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Lipid Metabolism and Cancer (Division)
Member
From1 Jan 2012 → Today - Clinical and Experimental Endocrinology (Division)
Member
From1 Jan 2003 → 31 Dec 2011 - Department of Development and Regeneration (Department)
Member
From1 Oct 2000 → 31 Dec 2002
Infrastructure
1 - 2 of 2
- An high-throughput automated small molecule screening platform (Consortium coordinator)
- Next Generation Magnetic Resonance Mass Spectrometry. (Consortium coordinator)
Projects
21 - 30 of 51
- Mass spectrometry imaging as a next generation tool in the digital pathology of prostate cancer.From16 Oct 2017 → 31 May 2022Funding: FWO Strategic Basic Research Grant
- Sensitizing cancer cells to ferroptosis: a ‘radically’ different approach to tackle advanced and therapy-resistant cancerFrom1 Oct 2017 → 30 Sep 2018Funding: Private funding of national origin - undefined
- LipoScan: a mass spectrometry-based lipidomics platform for cancer diagnostics and target identificationFrom1 Oct 2017 → 31 Dec 2020Funding: IOF - Industrial Research Fund
- Integrated platform to validate vesicular trafficking-associated processes in neurodegenerative diseases.From1 Jun 2017 → 31 May 2021Funding: FWO Strategic Basic Research (SBO)
- A ‘futile’ fatty acid cycle as central mediator and exploitable target in cancer resistance to molecular targeted therapyFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Fatty acid metabolism as a key mediator of therapy resistance in BRAF-mutant malignant melanoma.From1 Jan 2017 → 31 Dec 2018Funding: Other federal scientific institutions
- The use of metabonomics and lipidomics in the discovery of new actionable vulnerabilities in BRAF-mutated melanomaFrom21 Dec 2016 → 28 Aug 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Implementation of Nano-Flow Technology in the KU Leuven Metabolomics/Lipidomics Expertise PlatformFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Fatty acid metabolism as central mediator and exploitable target in therapy-resistant malignant melanomaFrom15 Sep 2016 → 15 Sep 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Cell biology of the endo-/lysosomal proteostasis in cancer and neurodegeneration (LYSOCaN).From1 Oct 2015 → 30 Sep 2021Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 133
- Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer(2024)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation regulates mitochondrial 13-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels(2024)
Authors: Johan Swinnen
- Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.(2024)
Authors: Yingli Zhu, Yoke Chin Chai, Patrizia Agostinis, Johan Swinnen
Pages: 6 - Extracellular vesicle-associated cholesterol supports the regenerative functions of macrophages in the brain(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Targeting lipid metabolism to overcome therapy resistance in pancreatic cancer(2023)
Authors: Vincent de Laat, Johan Swinnen
- C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 1720 - 1747 - A fat lot of good: A novel monounsaturated fatty acid promotes prostate cancer growth and survival(2023)
Authors: Jonas Dehairs, Johan Swinnen
- Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity(2023)
Authors: Jonas Dehairs, Johan Swinnen
Pages: 666 - 679 - Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism(2023)
Authors: Zoë Van Acker, Katherine North, Jonas Dehairs, Johan Swinnen, Wim Annaert
Patents
1 - 5 of 5
- Screening methods for compounds modulating polyamine transport (Inventor)
- Combination treatment of arsenic oxide and antiandrogens (Inventor)
- Cancer phospholipidome (Inventor)
- CANCER PHOSPHOLIPIDOME (Inventor)
- PHOSPHOLIPID PROFILING OF CANCER (Inventor)