Researcher
Jef Rozenski
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 12
- Exploration of the pharmacokinetics of clindamycin and its metabolites in special patients: from bioanalysis to clinical relevanceFrom1 Oct 2021 → 30 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Streamlining the route of phosphonate XNA from chemistry to applicationFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Directed evolution of bioactive compounds: Azol(in)e-containing post-translationally modified peptidesFrom1 Apr 2019 → 1 Apr 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Drug design strategies against newly emerging viral diseasesFrom17 Oct 2016 → 30 Oct 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Development of XNA ligases as tools for synthetic biologyFrom22 Sep 2015 → 17 Oct 2019Funding: BOF - doctoral mandates, BOF - Doctoral projects
- Development of a xenozyme and an XNA ligase.From1 Oct 2014 → 30 Sep 2018Funding: BOF - Concerted Research Project from 1994
- Selection of nucleic acid chemistry for therapeutic aptamer design.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project
- Oligonucleotides as biochemical and therapeutic tools.From1 Jan 2011 → 31 Dec 2014Funding: FWO research project
Publications
11 - 20 of 82
- Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors(2021)
Authors: Dries De Ruysscher, Luping Pang, Stijn Lenders, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Recent progress in the LC-MS/MS analysis of oxidative stress biomarkers(2021)
Authors: Asmin Andries, Jef Rozenski, Pieter Vermeersch, Djalila Mekahli, Ann Van Schepdael
Pages: 402 - 428 - Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution(2020)
Authors: Jef Rozenski, Mikhail Abramov, Vitor Bernardes Pinheiro, Piet Herdewyn
- Drug design strategies against newly emerging viral diseases(2020)
Authors: Muhammad Usman Mirza, Mathy Froeyen, Jef Rozenski
- Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors(2020)
Authors: Luping Pang, Steff De Graef, Eveline Lescrinier, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase(2020)
Authors: Dries De Ruysscher, Luping Pang, Charles-Alexandre Mattelaer, Steff De Graef, Jef Rozenski, Sergei Strelkov, Eveline Lescrinier, Arthur Van Aerschot
- Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases(2019)
Authors: Manesh Nautiyal, Steff De Graef, Luping Pang, Jef Rozenski, Arthur Van Aerschot
- Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins(2019)
Authors: Michiel Vanmeert, Muhammad Usman Mirza, Stephen Weeks, Jef Rozenski, Mathy Froeyen, Piet Herdewyn, Vitor Bernardes Pinheiro, Eveline Lescrinier
Pages: 1 - 12 - Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily(2019)
Authors: Dries De Ruysscher, Luping Pang, Steff De Graef, Manesh Nautiyal, Wim De Borggraeve, Jef Rozenski, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pages: 252 - 264 - Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA)(2019)
Authors: Elisabetta Groaz, Mathy Froeyen, Piotr Leonczak, Jef Rozenski, Piet Herdewyn
Pages: 10844 - 10851