< Back to previous page
Researcher
Jan Parys
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → Today
Projects
1 - 10 of 17
- A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cellsFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeuticsFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Physiological significance of pyruvate kinase M2 interaction with the IP3 receptor and its application as a new way to induce apoptosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membraneFrom1 Oct 2016 → 21 Jan 2021Funding: BOF - doctoral mandates
- Novel insights in the interplay between ryanodine receptors and Bcl-2 proteins.From1 Oct 2015 → 30 Sep 2016Funding: BOF - Other initiatives
- Crosstalk in the Ca2+ microdomain between lysosomes and endoplasmic reticulum controls the autophagic process.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Insights into the pathways implicated in the addiction of cancer B-cells to Bcl-2 at the endoplasmic reticulumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- The role of lysosomal Ca2+ in the regulation of autophagyFrom1 Sep 2014 → 10 Dec 2019Funding: FWO fellowships, BOF - Doctoral projects
- A novel concept in the biology of Bcl-2 proteins: primed to death at the endoplasmic reticulum.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressorsFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
31 - 40 of 160
- The Eighth ECS Workshop on "Calcium Signaling in Aging and Neurodegenerative Diseases"(2019)
Authors: Jan Parys
- L-asparaginase-induced apoptosis in ALL cells involves IP3 receptor signaling(2019)
Authors: Tim Vervliet, Jan Parys
- Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output(2019)
Authors: Hristina Ivanova, Elien Vandermarliere, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 3843 - 3859 - Full focus on calcium(2019)
Authors: Jan Parys
- Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells(2019)
Authors: Jan Parys
Pages: 1475 - 1486 - The emerging interrelation between ROCO and related kinases, intracellular Ca2+ signaling, and autophagy(2019)
Authors: Elzbieta Kania, Jan Parys
Pages: 1054 - 1067 - Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2(2019)
Authors: Mart Bittremieux, Rita La Rovere, Myriam Baes, Ann Janssens, Peter Vandenberghe, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 531 - 547 - Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death(2018)
Authors: Jan Parys, Geert Bultynck
Pages: 48 - 61 - The multifaceted STAT3: How a transcription factor regulates Ca2+ signaling via a degradative pathway(2018)
Authors: Jan Parys
Pages: 137 - 139 - The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner(2018)
Authors: Gemma Roest, Evelien Hesemans, Geert Bultynck, Jan Parys