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Researcher
Jan Tytgat
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Toxicology and Pharmacology (Division)
Responsible
From1 Jan 2012 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 26
- Improving Bees' Resilience to Stressors by Restoring Harmony and BalanceFrom1 Jun 2023 → TodayFunding: Horizon Europe - Food, Bioeconomy, Natural Resources, Agriculture and Environment
- Functional characterisation of Transient Receptor Potential Vanilloid (TRPV2) as a potential new target for endometrial cancerFrom1 Oct 2021 → TodayFunding: FWO junior postdoctoral fellowship
- Functional characterisation of Transient Receptor Potential Vanilloid (TRPV2) in uterine stroma - a potential new target for endometrial cancerFrom1 Mar 2020 → 28 Feb 2021Funding: BOF - postdoctoral mandates
- Ion channel ligands with unique selectivityFrom1 Jan 2020 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- PROBIO PROspection for BIOactive compounds in the North SeaFrom1 Nov 2019 → 30 Apr 2022Funding: VLAIO - Blue Cluster - ICON
- Targeting cannabinoid receptor signaling for drug discovery and characterization: A focus on CB1 and CB2 cannabinoid receptors and GIRK1/GIRK2 potassium channelsFrom19 Sep 2019 → 5 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Conopeptides as tools for studying pacemaker channels and for the development of novel cardiovascular drugsFrom9 Jan 2019 → 12 Dec 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Molecular elucidation of the unique gating behavior of cardiac ion channels thanks to their interaction with conopeptides.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- The epigenetic effects of air pollutants on human Amniotic Fluid Stem Cells (hAFSCs)From1 Nov 2017 → 28 Jul 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
41 - 50 of 302
- Functional Characterization of the Nemertide alpha Family of Peptide Toxins(2021)
Authors: Steve Peigneur, Jan Tytgat
Pages: 2121 - 2128 - Cyclic Peptides as T-Type Calcium Channel Blockers: Characterization and Molecular Mapping of the Binding Site(2021)
Authors: Anne-Sophie Depuydt, Jérôme Rihon, Eveline Lescrinier, Steve Peigneur, Jan Tytgat
Pages: 1 - 11 - Isolation and characterization of FMRFamide-like peptides in the venoms of solitary sphecid wasps(2021)
Authors: Steve Peigneur, Jan Tytgat
- Derivative of Scorpion Neurotoxin BeM9 Is Selective for Insect Voltage-Gated Sodium Channels(2021)
Authors: Steve Peigneur, Jan Tytgat
Pages: 854 - 863 - Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges(2021)
Authors: Louise Hendrickx, Steve Peigneur, Jan Tytgat
Pages: 2423 - 2473 - Potassium channel blocker crafted by α-hairpinin scaffold engineering(2021)
Authors: Steve Peigneur, Jan Tytgat
Pages: 2471 - 2481 - Anti-inflammatory and detoxification activities of some Ipomoea species determined by ion channel inhibition and their phytochemical constituents(2021)
Authors: Steve Peigneur, Jan Tytgat
Pages: 321 - 329 - WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels(2021)
Authors: Dongchen An, Steve Peigneur, Jan Tytgat
- Neurotoxic and convulsant effects induced by jack bean ureases on the mammalian nervous system(2021)
Authors: Steve Peigneur, Jan Tytgat
- Scorpion toxin MeuNaTxα-1 sensitizes primary nociceptors by selective modulation of voltage-gated sodium channels(2021)
Authors: Steve Peigneur, Jan Tytgat
Pages: 2418 - 2435