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Researcher
Jan Tytgat
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Toxicology and Pharmacology (Division)
Responsible
From1 Jan 2012 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 26
- Improving Bees' Resilience to Stressors by Restoring Harmony and BalanceFrom1 Jun 2023 → TodayFunding: Horizon Europe - Food, Bioeconomy, Natural Resources, Agriculture and Environment
- Functional characterisation of Transient Receptor Potential Vanilloid (TRPV2) as a potential new target for endometrial cancerFrom1 Oct 2021 → TodayFunding: FWO junior postdoctoral fellowship
- Functional characterisation of Transient Receptor Potential Vanilloid (TRPV2) in uterine stroma - a potential new target for endometrial cancerFrom1 Mar 2020 → 28 Feb 2021Funding: BOF - postdoctoral mandates
- Ion channel ligands with unique selectivityFrom1 Jan 2020 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- PROBIO PROspection for BIOactive compounds in the North SeaFrom1 Nov 2019 → 30 Apr 2022Funding: VLAIO - Blue Cluster - ICON
- Targeting cannabinoid receptor signaling for drug discovery and characterization: A focus on CB1 and CB2 cannabinoid receptors and GIRK1/GIRK2 potassium channelsFrom19 Sep 2019 → 5 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Conopeptides as tools for studying pacemaker channels and for the development of novel cardiovascular drugsFrom9 Jan 2019 → 12 Dec 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Discovery and mechanism of action of novel hEag1 potassium channel lead molecules with anti-cancer activity.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Molecular elucidation of the unique gating behavior of cardiac ion channels thanks to their interaction with conopeptides.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- The epigenetic effects of air pollutants on human Amniotic Fluid Stem Cells (hAFSCs)From1 Nov 2017 → 28 Jul 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 302
- Apamin structure and pharmacology revisited(2022)
Authors: Steve Peigneur, Jan Tytgat
- New Diarylamine KV10.1 Inhibitors and Their Anticancer Potential(2022)
Authors: Steve Peigneur, Jan Tytgat
- Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma(2022)
Authors: Steve Peigneur, Jan Tytgat
- Analytical performance of eight enzymatic assays for ethanol in serum evaluated by data from the Belgian external quality assessment scheme(2022)
Authors: Jan Tytgat
Pages: 1211 - 1217 - Discovery and mechanism of action of novel KV10.1 and KV1.3 potassium channel lead molecules with anti-cancer activity(2022)
Authors: Louise Hendrickx, Jan Tytgat, Steve Peigneur
- Review: HCN Channels in the Heart(2022)
Authors: Anne-Sophie Depuydt, Steve Peigneur, Jan Tytgat
- Pharmacological Screening of Venoms from Five Brazilian Micrurus Species on Different Ion Channels(2022)
Authors: Steve Peigneur, Jan Tytgat
- Design of New Potent and Selective Thiophene-Based KV1.3 Inhibitors and Their Potential for Anticancer Activity(2022)
Authors: Louise Hendrickx, Steve Peigneur, Jan Tytgat
- Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation(2022)
Authors: Steve Peigneur, Jan Tytgat
- Adaptively evolved human oral actinomyces-sourced defensins show therapeutic potential(2022)
Authors: Steve Peigneur, Jan Tytgat