Researcher
Jan Cools
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Hematology, Cancer biology
- See also: Cools J (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2008 → Today - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Dec 2017 → Today - Cools Lab (Research group)
Responsible
From1 Jan 2017 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2005 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Nov 2017
Projects
51 - 60 of 62
- Study of the role of protein tyrosine phosphatases in the pathogenesis of acute lymphoblastic leukemia.From1 Jan 2011 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- SymBioSys: from variome to phenome.From1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Deregulated signaling pathways in cancer: from genetic insights towards targeted therapy.From1 Oct 2010 → 30 Nov 2016Funding: BOF - Concerted Research Project from 1994
- Technical research platform & heavy equipment HiSeq200 (including CBOT computing system and warranty).From1 Sep 2010 → 31 Aug 2013Funding: Other federal scientific institutions
- Generation of primary acute lymphoblastic leukemia cell cultures for the development of moleculary targeted treatment appoaches.From1 Sep 2010 → 31 Aug 2013Funding: Private funding of national origin - undefined
- Protein Tyrosine Phosphorylation in Cancer Development and Applications for ResearchFrom1 Sep 2010 → 31 Dec 2014Funding: Nonprofit institution or equivalents
- Identification of recurrent genetic aberrations in BCR-ABL1 negative myeloproliferative neoplasms through an integrated genomic approach.From1 Jan 2010 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- role of VEGF and VEGF receptors in the pathogenesis of leukemiaFrom1 Sep 2009 → 31 Aug 2010Funding: Own budget, for example: patrimony, inscription fees, gifts
- Development of small molecules that interfere with the function of the transcription factor MYB for the treatment of leukemia.From1 Jan 2009 → 31 Dec 2011Funding: FWO research grant KAN
- Biacore T100 system (Health care).From20 Oct 2008 → 19 Apr 2015Funding: Hercules - Small and Medium size research infrastructure
Publications
1 - 10 of 201
- Single cell RNA sequencing reveals endothelial cell killing and resolution pathways in experimental malaria-associated acute respiratory distress syndrome(2024)
Authors: Emilie Pollenus, Sofie Demeyer, Jan Cools, Gianluca Matteoli, Jeroen Vanoirbeek, Greetje Vande Velde, Philippe Van den Steen
- Identification of novel targets for treatment in T-cell acute lymphoblastic leukemia(2023)
Authors: Inge Govaerts, Jan Cools
- Clonal Heterogeneity and Evolution during Treatment in High Hyperdiploid B-Cell Acute Lymphoblastic Leukemia(2023)
Authors: Margo Aertgeerts, Jolien De Bie, Lucienne Michaux, Jan Cools, Heidi Segers
- CRISPR screening in hematology research: from bulk to single-cell level(2023)
Authors: Sarah Meyers, Sofie Demeyer, Jan Cools
- Combination therapy of a PSEN1-selective γ-secretase inhibitor with dexamethasone and an XPO1 inhibitor to target T-cell acute lymphoblastic leukemia(2023)
Authors: Charlien Vandersmissen, David Nittner, Johan Maertens, Heidi Segers, Jan Cools
Pages: 2507 - 2512 - Targeting STAT5B in T-cell acute lymphoblastic leukemia(2023)
Authors: Jan Cools
Pages: 215 - 217 - Primary mediastinal large B-cell lymphoma is hallmarked by large-scale copy-neutral loss of heterozygosity(2023)
Authors: Jonas Demeulemeester, Lucienne Michaux, Jan Cools, Thomas Tousseyn
Pages: 525 - 525 - Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer(2023)
Authors: Elien Heylen, Paulien Verstraete, Linde Van Aerschot, Tom Venken, David Nittner, Anne Uyttebroeck, Heidi Segers, Diether Lambrechts, Jan Cools, Kim De Keersmaecker, et al.
Pages: 1862 - 1878 - A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling(2023)
Authors: Ginevra Doglioni, Alex Cuadros, Xiaozheng Liu, dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Margherita Demicco, François Richard, Tatjana Geukens, Maxim De Schepper, et al.
Pages: 344 - + - Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma(2022)
Authors: Marlies Vanden Bempt, Koen Debackere, Sofie Demeyer, Quentin Van Thillo, Nienke Meeuws, David Nittner, Thomas Tousseyn, Jan Cools, Daan Dierickx
Pages: 2463 - 2476
Patents
1 - 2 of 2