Researcher
Jan Cools
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Hematology, Cancer biology
- See also: Cools J (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2008 → Today - Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven) (Division)
Member
From1 Dec 2017 → Today - Cools Lab (Research group)
Responsible
From1 Jan 2017 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2004 → 30 Sep 2005 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Nov 2017
Projects
1 - 10 of 62
- Molecular characterization of hyperactive T cell receptor signaling in peripheral T cell lymphoma to uncover druggable targetsFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular characterization of genetic events driving development of peripheral T cell lymphomaFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- GAINING INSIGHT IN THE MUTATIONAL PROFILE OF PT-DLBCL AND ASSESSING ITS BIOLOGICAL EFFECTS AND TRANSFORMING POTENTIALFrom2 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Degradation of CDK1 and HDACs as a strategy to treat T-cell malignanciesFrom1 Oct 2023 → TodayFunding: BOF - projects
- Uncovering mechanisms of TLX1/TLX3 oncogenic cooperation in leukemiaFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- EZH2 as a transcriptional activator in T-ALLFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- TLX transcriptional complexes in T-cell acute lymphoblastic leukemiaFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Mechanisms of resistance to current treatment of acute myeloid leukemiaFrom15 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Oncogene cooperation enhancing TLX1 positive leukemia developmentFrom1 Sep 2022 → TodayFunding: Other federal public and semi-governmental institutions
Publications
11 - 20 of 200
- TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia(2022)
Authors: Sofie Demeyer, Jan Cools
Pages: 2304 - 2317 - Primary mediastinal large B-cell lymphoma is characterized by large-scale copy-neutral loss of heterozygosity(2022)
Authors: Stefania Tuveri, Koen Debackere, Lukas Marcelis, Nicolas Dierckxsens, Jonas Demeulemeester, Eftychia Dimitriadou, Daan Dierickx, Lucienne Michaux, Jan Cools, Thomas Tousseyn, et al.
Pages: 603 - 615 - Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters(2022)
Authors: Sofie Demeyer, Jan Cools
- Oncogenic cooperation in T-cell acute lymphoblastic leukemia: the role of TLX3 and TCF7-SPI1(2022)
Authors: Quentin Van Thillo, Jan Cools, Charles De Bock
- PHGDH heterogeneity potentiates cancer cell dissemination and metastasis (vol 605. pg 747, 2022)(2022)
Authors: Margherita Demicco, Anke Vandekeere, Juan Fernandez Garcia, Carla Riera Domingo, David Nittner, Francesca Rizzollo, Panagiotis Karras, dorien Broekaert, Sofie Demeyer, Ayse Bassez, et al.
Pages: E8 - E8 - The Updated European Hematology Association Research Roadmap(2022)
Authors: Jan Cools
- PHGDH heterogeneity potentiates cancer cell dissemination and metastasis(2022)
Authors: Margherita Demicco, Ginevra Doglioni, Anke Vandekeere, Alex Cuadros, David Nittner, Francesca Rizzollo, Panagiotis Karras, dorien Broekaert, Sofie Demeyer, Guy Eelen, et al.
Pages: 747 - + - Optimizing the diagnostic workflow for acute lymphoblastic leukemia by optical genome mapping(2022)
Authors: Jolien De Bie, Sofie Demeyer, Jan Cools, Kim De Keersmaecker, Joris Vermeesch, Johan Maertens, Heidi Segers, Lucienne Michaux, Barbara Dewaele
Pages: 548 - 561 - Monitoring of Leukemia Clones in B-cell Acute Lymphoblastic Leukemia at Diagnosis and During Treatment by Single-cell DNA Amplicon Sequencing(2022)
Authors: Sarah Meyers, Jolien De Bie, Lucienne Michaux, Barbara Dewaele, Nancy Boeckx, Anne Uyttebroeck, Kim De Keersmaecker, Johan Maertens, Heidi Segers, Jan Cools, et al.
- Oncogene coöperatie in T-cel acute lymfatische leukemie(2021)
Authors: Inge Lodewijckx, Jan Cools
Patents
1 - 2 of 2