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Researcher
Jan Balzarini
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2016
Projects
1 - 6 of 6
- Exploration of carbohydrate-binding agents and (co)receptor inhibitors directed against HIV entry.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Exploration of the role of HIV envelope glycans on virus entry and the antiviral activity of carbohydrate-binding agents (CBAs)From29 Sep 2011 → 30 Sep 2015Funding: FWO fellowships
- The Rev-dependent nucleocytoplasmatic mRNA transport as a new target for anti-HIV therapyFrom1 Jan 2011 → 2 Jun 2015Funding: IWT personal funding - strategic basic research grants
- Viral infections: molecular insights, targets for intervention and drug developmentFrom1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
41 - 50 of 547
- High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300(2016)
Authors: Mariya Petrova, Sam Noppen, Sandra Liekens, Jan Balzarini, Dominique Schols, Jos Vanderleyden, Sarah Lebeer
Pages: 37339 - Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor(2016)
Authors: Graciela Andrei, Jan Balzarini, Robert Snoeck
Pages: 773 - 781 - Synthesis and biological evaluation of novel mononuclear Ru(II) compounds as potential antiviral and cytotoxic agents(2016)
Authors: Erik De Clercq, Graciela Andrei, Robert Snoeck, Jan Balzarini
Pages: 1491 - 1496 - Carbohydrate-binding non-peptidic pradimicins for the treatment of acute sleeping sickness in murine models(2016)
Authors: Sandra Liekens, Jan Balzarini
- Lectin-like molecules of Lactobacillus rhamnosus GG inhibit pathogenic Escherichia coli and Salmonella biofilm formation(2016)
Authors: Mariya Petrova, Jan Balzarini, Dominique Schols, Jos Vanderleyden, Sarah Lebeer
- Conformational states of HIV-1 reverse transcriptase for nucleotide incorporation vs pyrophosphorolysis-Binding of foscarnet(2016)
Authors: Kalyan Das, Jan Balzarini
Pages: 2158 - 2164 - Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones(2016)
Authors: Jan Balzarini, Erik De Clercq
Pages: 2206 - 14 - Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones(2016)
Authors: Sandra Liekens, Jan Balzarini
Pages: 579 - Membrane-permeable triphosphate prodrugs of nucleoside analogues(2016)
Authors: Dominique Schols, Jan Balzarini
Pages: 5255 - 5258 - Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics(2016)
Authors: Jan Balzarini, Dominique Schols, Graciela Andrei, Robert Snoeck
Pages: 1970 - 1972
Patents
1 - 10 of 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)