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Researcher
Jan Balzarini
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2016
Projects
1 - 6 of 6
- Exploration of carbohydrate-binding agents and (co)receptor inhibitors directed against HIV entry.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Exploration of the role of HIV envelope glycans on virus entry and the antiviral activity of carbohydrate-binding agents (CBAs)From29 Sep 2011 → 30 Sep 2015Funding: FWO fellowships
- The Rev-dependent nucleocytoplasmatic mRNA transport as a new target for anti-HIV therapyFrom1 Jan 2011 → 2 Jun 2015Funding: IWT personal funding - strategic basic research grants
- Viral infections: molecular insights, targets for intervention and drug developmentFrom1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- The effect of Mycoplasma enzymes on the antiviral and anticancer activity of nucleoside analoguesFrom1 Jun 2008 → 2 Dec 2013Funding: IWT personal funding - strategic basic research grants
Publications
21 - 30 of 547
- The ProTide Prodrug Technology: From the Concept to the Clinic(2018)
Authors: Jan Balzarini
Pages: 2211 - 2226 - 2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells(2018)
Authors: Sam Noppen, Wim Dehaen, Jan Balzarini, Sandra Liekens
Pages: 6259 - 6269 - 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition(2018)
Authors: Jan Balzarini, Sandra Liekens
Pages: 683 - 698 - Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases (vol. 33, pg. 775, 2017)(2017)
Authors: Victor M Castillo-Acosta, Jan Balzarini, Dolores Gonzalez-Pacanowska
Pages: 1003 - 1004 - Surface glycans: A therapeutic opportunity for kinetoplastid diseases(2017)
Authors: Jan Balzarini
Pages: 775 - 787 - New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity(2017)
Authors: Robert Snoeck, Jan Balzarini, Graciela Andrei
Pages: 4637 - 4648 - Virtual screening of acyclovir derivatives as potential antiviral agents: Design, synthesis, and biological evaluation of new acyclic nucleoside ProTides(2017)
Authors: Graciela Andrei, Robert Snoeck, Jan Balzarini
Pages: 7876 - 7896 - Synthesis and biological activity of novel phenol-conjugates of isoxazolidines(2017)
Authors: Jan Balzarini, Graciela Andrei, Dominique Schols, Robert Snoeck
Pages: 1091 - 1100 - Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses(2017)
Authors: Jan Balzarini, Kalyan Das, Sandra Liekens
Pages: 51 - 61 - A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes(2017)
Authors: Sampad Jana, Jan Balzarini, Sandra Liekens, Wim Dehaen
Pages: 3892 - 3900
Patents
1 - 10 of 10
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Novel anti-cancer thiophene compounds (Inventor)
- Pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- New pradimicin derivatives for the treatment of diseases caused by kinetoplastids (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer (Inventor)
- Phosphonucleosides useful in the treatment of viral disorders (Inventor)
- Phosphonate nucleosides useful in the treatment of viral diseases (Inventor)
- Anti-cancer compounds (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)