Researcher
Humbert De Smedt
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → 30 Sep 2018
Projects
1 - 10 of 12
- The role of Ca and mTOR signaling in the pathogenesis of autosomal dominant polycystic diseaseFrom1 Oct 2013 → 13 Dec 2018Funding: FWO fellowships
- The role of Ca2+ signaling for cyst formation in autosomal dominant polycystic kidney diseaseFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Exploiting Ca2+ signaling and altered IP3R function in Bcell lymphomasFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Nieuwe functies voor het BH4 domein van Bcl-2: een kritische regulator van Ca2+-permeable kanalen.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Molecular determinants of Bcl–2 and Bcl–Xl binding to the IP3R channel and regulation of its activity at the molecular and functional level in normal and apoptotic cellsFrom1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
- Profiling of pro-apoptotic Ca2+ signaling in cancer cells.From1 Oct 2009 → 30 Sep 2012Funding: FWO fellowships
- Role of connexins and pannexins in programmed cell death.From1 Oct 2009 → 30 Sep 2013Funding: FWO fellowships
- Autosomal Dominant Polycystic Kidney Disease: From bedside to bench and backFrom5 Jan 2009 → 13 Dec 2012Funding: Own budget, for example: patrimony, inscription fees, gifts
- Intracellular calcium stores and programmed cell death.From1 Jan 2009 → 31 Dec 2012Funding: FWO research project
- Role of connexins and pannexins in programmed cell death.From29 Dec 2008 → 30 Dec 2009Funding: BOF - Other initiatives
Publications
1 - 10 of 73
- PKD2/polycystin-2 induces autophagy by forming a complex with BECN1(2021)
Authors: Humbert De Smedt
Pages: 1714 - 1728 - Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output(2019)
Authors: Hristina Ivanova, Elien Vandermarliere, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 3843 - 3859 - Fundamental insights into autosomal dominant polycystic kidney disease from human-based cell models(2019)
Authors: Jean-Paul Decuypere, Humbert De Smedt, Rudi Vennekens, Djalila Mekahli
Pages: 1697 - 1715 - Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2(2019)
Authors: Mart Bittremieux, Rita La Rovere, Myriam Baes, Ann Janssens, Peter Vandenberghe, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 531 - 547 - Polycystin-2-dependent control of cardiomyocyte autophagy(2018)
Authors: Humbert De Smedt
Pages: 110 - 121 - A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for BH4 domain in both protein stability and function(2018)
Authors: Giovanni Monaco, Rita La Rovere, Lily Karamanou, Hristina Ivanova, Elien Vandermarliere, Humbert De Smedt, Jan Parys, Tassos Economou, Geert Bultynck
Pages: 127 - 145 - Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax(2017)
Authors: Tamara Vervloessem, Haidar Akl, Thomas Tousseyn, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 111656 - 111671 - Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease(2017)
Authors: Frederik Temmerman, Louis Libbrecht, YUanbo Feng, Yicheng Ni, Humbert De Smedt, Frederik Nevens, Jos van Pelt
Pages: 5499 - 5507 - Molecular determinants underlying the modulation of IP3R activity by anti-apoptotic Bcl-2 versus Bcl-Xl proteins(2017)
Authors: Hristina Ivanova, Geert Bultynck, Humbert De Smedt, Jan Parys
- DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store(2017)
Authors: Mart Bittremieux, Humbert De Smedt, Peter Vangheluwe, Jan Parys, Geert Bultynck
Pages: 60 - 70