Researcher
Hristina Ivanova
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Mar 2012 → 31 Oct 2019
Projects
1 - 2 of 2
- An integrated molecular, functional and structural characterization of the determinants, underlying the multi-domain complexes between IP3 receptors and anti-apoptotic Bcl-2 and Bcl-Xl proteinsFrom1 Oct 2017 → 1 Nov 2019Funding: FWO fellowships
- Molecular determinants of Bcl–2 and Bcl–Xl binding to the IP3R channel and regulation of its activity at the molecular and functional level in normal and apoptotic cellsFrom1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
Publications
1 - 10 of 16
- Bcl-2-protein family as modulators of IP₃ receptors and other organellar Ca²⁺ channels(2020)
Authors: Hristina Ivanova, Tim Vervliet, Giovanni Monaco, Nicolas Rosa, Jan Parys, Geert Bultynck
- Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output(2019)
Authors: Hristina Ivanova, Elien Vandermarliere, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 3843 - 3859 - Pathophysiological consequences of isoform-specific IP3 receptor mutations(2018)
Authors: Martijn Kerkhofs, Bruno Seitaj, Hristina Ivanova, Giovanni Monaco, Geert Bultynck, Jan Parys
Pages: 1707 - 1717 - Modulation of IP₃ receptor stability and its implication in cell death and disease(2018)
Authors: Bruno Seitaj, Geert Bultynck, Hristina Ivanova
Pages: 9 - 21 - A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for BH4 domain in both protein stability and function(2018)
Authors: Giovanni Monaco, Rita La Rovere, Lily Karamanou, Hristina Ivanova, Elien Vandermarliere, Humbert De Smedt, Jan Parys, Tassos Economou, Geert Bultynck
Pages: 127 - 145 - The selective Bcl-2 inhibitor venetoclax, a BH3 mimetic, does not dysregulate intracellular Ca2+ signaling(2017)
Authors: Tamara Vervloessem, Hristina Ivanova, Jan Parys, Geert Bultynck
Pages: 968 - 976 - Molecular determinants underlying the modulation of IP3R activity by anti-apoptotic Bcl-2 versus Bcl-Xl proteins(2017)
Authors: Hristina Ivanova, Geert Bultynck, Humbert De Smedt, Jan Parys
- Endoplasmic Reticulum-Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival(2017)
Authors: Hristina Ivanova, Martijn Kerkhofs, Rita La Rovere, Geert Bultynck
- Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface(2017)
Authors: Tim Vervliet, Eva Clerix, Bruno Seitaj, Hristina Ivanova, Giovanni Monaco, Geert Bultynck
- The BH4 domain of Bcl-2 orthologues from different classes of vertebrates can act as an evolutionary conserved inhibitor of IP3 receptor channels(2017)
Authors: Hristina Ivanova, Tim Vervliet, Jan Parys, Geert Bultynck
Pages: 41 - 46