Researcher
Hilde Brems
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Neurofibromatosis Research (Division)
Responsible
From15 Jul 2022 → Today - Laboratory for Neurofibromatosis Research (Division)
Member
From19 Oct 2009 → 30 Sep 2017 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 7 of 7
- Molecular and functional characterization of Legius syndrome and related disorders: Improved diagnosis and understanding of the underlying mechanisms.From1 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases”From1 Aug 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Importance of SPRED1 in melanomaFrom9 Dec 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Importance of SPRED1 in melanomaFrom1 Oct 2015 → 27 Mar 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Periosteal cell therapy as a new treatment of pseudarthrosis in children with NF1.From21 Oct 2013 → 10 Dec 2019Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
- Pathogenesis of congenital tibial bowing and pseudarthrosis in neurofibromatosis type 1.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project
- NF1-like syndromes: identification of new genes and further characterization of Legius syndrome using the mouse model.From1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
Publications
11 - 20 of 84
- PARP inhibitor predictive value of the Leuven HRD test compared with Myriad MyChoice CDx PLUS HRD on 468 ovarian cancer patients from the PAOLA-1/ENGOT-ov25 trial(2023)
Authors: Liselore Loverix, Ignace Vergote, Pieter Busschaert, Tom Venken, Bram Boeckx, Hilde Brems, Els Van Nieuwenhuysen, Thaïs Baert, Sileny Han, Patrick Neven, et al.
Pages: 131 - 139 - Preclinical workup using long-read amplicon sequencing provides families with de novo pathogenic variants access to universal preimplantation genetic testing(2023)
Authors: Olga Tsuiko, Tatjana Jatsenko, Sophie Debrock, Karen Peeraer, Arne Vanhie, Ellen Denayer, Eric Legius, Joris Vermeesch, Hilde Brems, Eftychia Dimitriadou
Pages: 511 - 519 - Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis(2023)
Authors: Eric Legius, Hilde Brems
- Genotype-first approach to identify associations between CDH1 germline variants and cancer phenotypes: a multicentre study by the European Reference Network on Genetic Tumour Risk Syndromes(2023)
Authors: Hilde Brems
Pages: 91 - 106 - Genotype-phenotype associations in a large PTEN Hamartoma Tumor Syndrome (PHTS) patient cohort(2022)
Authors: Eric Legius, Hilde Brems
- Identification of Codon 146 KRAS Variants in Isolated Epidermal Nevus and Multiple Lesions in Oculoectodermal Syndrome: Confirmation of the Phenotypic Continuum of Mosaic RASopathies(2022)
Authors: Hilde Brems
- Prevalence of microsatellite instable and Epstein-Barr Virus-driven gastro-esophageal cancer in a large Belgian cohort(2022)
Authors: Xavier Sagaert, Hilde Brems, Carlijn Brekelmans, Philippe Nafteux, Baki Topal, Chris Verslype, Sabine Tejpar, Jeroen Dekervel
- An update on Congenital Melanocytic Nevus Syndrome: a case report and literature review.(2021)
Authors: Francesca Bosisio, Hilde Brems, Greet De Vlieger, Maria Garmyn, Heidi Segers, Philippe Demaerel, Katrien Jansen, Lieven Lagae
Pages: 1497 - 1503 - Comprehensive immunomolecular profiling of endometrial carcinoma: A tertiary retrospective study(2021)
Authors: Sara Vander Borght, Lien Spans, Hilde Brems, Annouschka Laenen, Ignace Vergote, Toon Van Gorp, Els Van Nieuwenhuysen, Sileny Han, Stefan Timmerman, Anne-Sophie Van Rompuy, et al.
Pages: 694 - 701 - Multitumor Case Series of Germline BRCA1, BRCA2 and CHEK2-Mutated Patients Responding Favorably on Immune Checkpoint Inhibitors.(2021)
Authors: Lisa Kinget, Oliver Bechter, Kevin Punie, Hilde Brems, Paul Clement, Eduard Roussel, Yannick Van Herck, Maarten Albersen, Marcella Baldewijns, Patrick Schöffski, et al.
Pages: 3227 - 3239