Researcher
Hilde Brems
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Neurofibromatosis Research (Division)
Responsible
From15 Jul 2022 → Today - Laboratory for Neurofibromatosis Research (Division)
Member
From19 Oct 2009 → 30 Sep 2017 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 9 of 9
- From clinical to molecular diagnostics of mosaic neurofibromatosis type 1 (NF) and back: Tackling the right cells.From12 Sep 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular and functional characterization of Legius syndrome and related disorders: Improved diagnosis and understanding of the underlying mechanisms.From1 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases”From1 Aug 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Building the EU Cancer and Public Health Genomics platformFrom1 Nov 2022 → TodayFunding: HORIZON.2.1 - Health, Other EU initiatives out of framework
- Importance of SPRED1 in melanomaFrom9 Dec 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Importance of SPRED1 in melanomaFrom1 Oct 2015 → 27 Mar 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Periosteal cell therapy as a new treatment of pseudarthrosis in children with NF1.From21 Oct 2013 → 10 Dec 2019Funding: IWT personal funding - strategic basic research grants, BOF - Doctoral projects
- Pathogenesis of congenital tibial bowing and pseudarthrosis in neurofibromatosis type 1.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project
- NF1-like syndromes: identification of new genes and further characterization of Legius syndrome using the mouse model.From1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
Publications
1 - 10 of 81
- Encephalocraniocutaneous lipomatosis phenotype associated with mosaic biallelic pathogenic variants in the NF1 gene(2024)
Authors: Steven Smeijers, Hilde Brems, Wim Van Paesschen, Johan van Loon, Seppe Van der Auweraer, Raf Sciot, Dietmar Thal, Lieven Lagae, Eric Legius, Tom Theys
- Constitutional mismatch repair deficiency mimicking Lynch syndrome is associated with hypomorphic mismatch repair gene variants(2024)
Authors: Jeroen Dekervel, Gert De Hertogh, Hilde Brems, Eric Legius
- Mosaic RASopathies concept: different skin lesions, same systemic manifestations?(2024)
Authors: Hilde Brems
Pages: 411 - 419 - Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)(2024)
Authors: Hilde Brems
- Gonadal and gonadosomatic mosaicism in NF1: report of two families(2024)
Authors: Eric Legius, Hilde Brems
Pages: 429 - 429 - Gonadal and gonadosomatic mosaicism in NF1: report of two families(2024)
Authors: Eric Legius, Hilde Brems
Pages: 426 - 429 - Capillary malformations in a child caused by a novel HRAS mutation(2024)
Authors: Eric Legius, Hilde Brems
Pages: 289 - 291 - Germline founder variant c.1998delinsTTCT in the RET oncogene: a cohort study in 15 Belgian families(2023)
Authors: Hilde Brems, Anne Uyttebroeck, Eric Legius, Brigitte Decallonne
Pages: 402 - 408 - PARP inhibitor predictive value of the Leuven HRD test compared with Myriad MyChoice CDx PLUS HRD on 468 ovarian cancer patients from the PAOLA-1/ENGOT-ov25 trial(2023)
Authors: Liselore Loverix, Ignace Vergote, Pieter Busschaert, Tom Venken, Bram Boeckx, Hilde Brems, Els Van Nieuwenhuysen, Thaïs Baert, Sileny Han, Patrick Neven, et al.
Pages: 131 - 139 - Preclinical workup using long-read amplicon sequencing provides families with de novo pathogenic variants access to universal preimplantation genetic testing(2023)
Authors: Olga Tsuiko, Tatjana Jatsenko, Sophie Debrock, Karen Peeraer, Arne Vanhie, Ellen Denayer, Eric Legius, Joris Vermeesch, Hilde Brems, Eftychia Dimitriadou
Pages: 511 - 519