Researcher
Henry Heimberg
- Research Expertise:
(i) glucose sensing system in alpha- and beta cells, (ii) transcription factors that support the phenotype of beta cells and control reprogramming of non-beta cells of the endocrine pancreas, (iii) development of experimental models to study beta cell neogenesis by differentiation from stem/progenitor cells and by proliferation of preexisting and newly formed beta cells.
- Keywords:Medicine
- Disciplines:Endocrinology
- Users of research expertise:
(i) glucose sensing system in alpha- and beta cells, (ii) transcription factors that support the phenotype of beta cells and control reprogramming of non-beta cells of the endocrine pancreas, (iii) development of experimental models to study beta cell neogenesis by differentiation from stem/progenitor cells and by proliferation of preexisting and newly formed beta cells.
Affiliations
- Beta Cell Neogenesis (Research group)
Member
From1 Jan 2007 → Today - Basic (bio-) Medical Sciences (Department)
Member
From1 Oct 2023 → Today - Pathology/molecular and cellular medicine (Department)
Member
From8 Apr 2019 → Today - Pathology/molecular and cellular medicine (Department)
Member
From1 Jan 2014 → 20 Oct 2022 - Medical Biochemistry (Department)
Member
From1 Jul 2004 → 31 Dec 2013 - Pathologic Biochemistry and Physiology (Department)
Member
From1 Jan 2001 → 30 Jun 2004 - Pathologic Biochemistry and Physiology (Department)
Member
From1 Oct 1996 → 30 Sep 2005 - Medical Biochemistry (Department)
Member
From1 Dec 1988 → 30 Sep 1994
Projects
1 - 10 of 16
- Deciphering the involvement of iron metabolism in beta cell differentiation, maturation, and function.From1 Nov 2022 → TodayFunding: FWO fellowships
- Designing a microenvironment for beta cell proliferationFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Making Human Beta Cells by Reprogramming Exocrine PancreasFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Insulin-producing cells in Drosophila, mouse and man: A multidisciplinary approach to study and treat diabetes.From1 Oct 2015 → 30 Jun 2016Funding: FWO fellowships
- ULB-VUB Joint Research Group: Brussels Diabetes Research Pole - BDRPFrom5 Nov 2014 → 3 Nov 2022Funding: University - Project driven research
- The mechanism of cytokine-induced beta-cell neogenesis by reprogramming of acinar cells in the pancreas as a treatment for diabetes.From1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- SRP (Groeiers): Regenerative therapy in diabetesFrom1 Mar 2014 → 28 Feb 2019Funding: BOF - Concerted Research Project from 1994
- The Neurogenin 3 cell as a guide for cell therapy in diabetes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- The role of Ngn3 to induce beta cell neogenesis and signals that activate the Ngn3 gene expressionFrom1 Oct 2012 → 30 Sep 2016Funding: FWO fellowships
- Biological compounds to regenerate the beta cell mass in diabetesFrom1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
Publications
41 - 50 of 61
- Conditional hypovascularization and hypoxia in islets do not overtly influence adult β cell mass and function(2013)
Authors: Joke D'Hoker, Nico De Leu, Yves Heremans, L Baeyens, Kohtaro Minami, Ying Cai, Astrid Marie-Therese Lavens, Marie Chintinne, Geert M Stangé, Judith Magenheim, et al.
Pages: 4165-4173 - Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr/R-spondin axis(2013)
Authors: Merixtell Huch, Paola Bonfanti, Sylvia Boj, Toshiro Sato, Cindy Loomans, Marc Van De Wetering, Mozhdeh Sojoodi, Vivian Li, Jurian Schuijers, Ana Gracanin, et al.
Pages: 2708-2721 - The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells(2013)
Authors: Monica Courtney, Elisabet Gjernes, Noémie Druelle, Christophe Ravaud, Andhira Vieira, Nouha Ben_othman, Anja Pfeifer, Fabio Avolio, Gunter Leuckx, Sandra Lacas-Gervais, et al.
Pages: 1003934 - Suppression of epithelial to mesenchymal transitioning (EMT) enhances ex vivo reprogramming of human exocrine pancreatic tissue towards functional insulin producing β-like cells(2013)
Authors: Maria Joao Lima, Kenneth Muir, Hilary Docherty, Robert Drummond, Neil Mcgowan, Shareen Forbes, Yves Heremans, I Houbracken, James Ross, Philippe Ravassard, et al.
Pages: 2821-2833 - Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells(2013)
Authors: Anujith Kumar, Antonio Lo Nigro, Conny Gysemans, Qing Cai, Camilla Esguerra, Molly Nelson-Holte, Yves Heremans, Marıa Jiminez-Gonzalez, Angelo Porciuncula, Chantal Mathieu, et al.
Pages: 63491 - Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration(2013)
Authors: Fong Cheng Pan, Eric Bankaitis, Daniel Boyer, Xiaobo Xu, Mark Van de Casteele, Mark Magnuson, Henry Heimberg, Christopher Wright
Pages: 751-764 - Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas(2013)
Authors: Mark Van de Casteele, Gunter Leuckx, L Baeyens, Ying Cai, Yixing Yuchi, V Coppens, Sofie De Groef, M Eriksson, C. Svensson, U Ahlgren, et al.
- Differentiating neural crest stem cells induce proliferation of cultured rodent islet beta cells(2012)
Authors: Gael Grouwels, Svetlana Vasylovska, Johan Olerud, Gunter Leuckx, Anongnad Ngamjaeiyawat, Yixing Yuchi, Leif Jansson, Mark Van de Casteele, Elena Kozlova, Henry Heimberg
Pages: 2016-2025 - Role of the ductal transcription factors HNF6 and Sox9 in pancreaticacinar-to-ductal metaplasia(2012)
Authors: Pierre-Paul Prevot, Alexandru Simion, Adrien Grimont, Marta Colletti, Abed Khalaileh, Geraldine Van Den Steen, Christine Sempoux, Xiaobo Xu, Veronique Roelants, Jacob Hald, et al.
Pages: 1723-1732 - Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming(2012)
Authors: Nathalie Swales, Geert A Martens, Stefan Bonne, Yves Heremans, Rehannah Borup, Mark Van de Casteele, Zhidong Ling, Danny Pipeleers, Philippe Ravassard, Jorge Ferrer, et al.
Pages: 37055