Researcher
Henry Heimberg
- Research Expertise:
(i) glucose sensing system in alpha- and beta cells, (ii) transcription factors that support the phenotype of beta cells and control reprogramming of non-beta cells of the endocrine pancreas, (iii) development of experimental models to study beta cell neogenesis by differentiation from stem/progenitor cells and by proliferation of preexisting and newly formed beta cells.
- Keywords:Medicine
- Disciplines:Endocrinology
- Users of research expertise:
(i) glucose sensing system in alpha- and beta cells, (ii) transcription factors that support the phenotype of beta cells and control reprogramming of non-beta cells of the endocrine pancreas, (iii) development of experimental models to study beta cell neogenesis by differentiation from stem/progenitor cells and by proliferation of preexisting and newly formed beta cells.
Affiliations
- Beta Cell Neogenesis (Research group)
Member
From1 Jan 2007 → Today - Basic (bio-) Medical Sciences (Department)
Member
From1 Oct 2023 → Today - Pathology/molecular and cellular medicine (Department)
Member
From8 Apr 2019 → Today - Pathology/molecular and cellular medicine (Department)
Member
From1 Jan 2014 → 20 Oct 2022 - Medical Biochemistry (Department)
Member
From1 Jul 2004 → 31 Dec 2013 - Pathologic Biochemistry and Physiology (Department)
Member
From1 Jan 2001 → 30 Jun 2004 - Pathologic Biochemistry and Physiology (Department)
Member
From1 Oct 1996 → 30 Sep 2005 - Medical Biochemistry (Department)
Member
From1 Dec 1988 → 30 Sep 1994
Projects
1 - 10 of 16
- Deciphering the involvement of iron metabolism in beta cell differentiation, maturation, and function.From1 Nov 2022 → TodayFunding: FWO fellowships
- Designing a microenvironment for beta cell proliferationFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Making Human Beta Cells by Reprogramming Exocrine PancreasFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Insulin-producing cells in Drosophila, mouse and man: A multidisciplinary approach to study and treat diabetes.From1 Oct 2015 → 30 Jun 2016Funding: FWO fellowships
- ULB-VUB Joint Research Group: Brussels Diabetes Research Pole - BDRPFrom5 Nov 2014 → 3 Nov 2022Funding: University - Project driven research
- The mechanism of cytokine-induced beta-cell neogenesis by reprogramming of acinar cells in the pancreas as a treatment for diabetes.From1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- SRP (Groeiers): Regenerative therapy in diabetesFrom1 Mar 2014 → 28 Feb 2019Funding: BOF - Concerted Research Project from 1994
- The Neurogenin 3 cell as a guide for cell therapy in diabetes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- The role of Ngn3 to induce beta cell neogenesis and signals that activate the Ngn3 gene expressionFrom1 Oct 2012 → 30 Sep 2016Funding: FWO fellowships
- Biological compounds to regenerate the beta cell mass in diabetesFrom1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
Publications
31 - 40 of 61
- Concise Review - Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration(2015)
Authors: Naomi Van Gassen, Willem Staels, Eva Van Overmeire, Sofie De Groef, Mozhdeh Sojoodi, Yves Heremans, Gunter Leuckx, Mark Van de Casteele, Jo A Van Ginderachter, Henry Heimberg, et al.
Pages: 555-563 - In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression(2015)
Authors: Caroline B Sangan, Ramiro Jover, Henry Heimberg, David Tosh
Pages: 50-59 - Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture(2015)
Authors: Kenneth R Muir, Maria Joao Lima, Hilary M Docherty, Neil W A McGowan, Shareen Forbes, Yves Heremans, Stuart J Forbes, Henry Heimberg, John Casey, Kevin Docherty
- Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation(2015)
Authors: Sofie De Groef, Gunter Leuckx, Naomi Van Gassen, Willem Staels, Ying Cai, Yixing Yuchi, Violette Coppens, Nico De Leu, Yves Heremans, L Baeyens, et al.
- Inducible VEGF expression by human embryonic stem cell-derived mesenchymal stromal cells reduces the minimal islet mass required to reverse diabetes(2015)
Authors: E Hajizadeh-Saffar, Y Tahamtani, N Aghdami, Keyhan Azadmanesh, Mahdi Habibi Anbouhi, Yves Heremans, Nico De Leu, Henry Heimberg, Philippe Ravassard, M A Shokrgozar, et al.
- Estrogen Receptor α Regulates Beta Cell Formation During Pancreas Development and Following Injury(2015)
Authors: Yixing Yuchi, Ying Cai, Bart Legein, Sofie De Groef, Gunter Leuckx, Violette Coppens, Eva Van Overmeire, Willem Staels, Nico De Leu, Geert Martens, et al.
Pages: 3218-3228 - Combining MK626, a novel DPP-4 inhibitor, and low- dose monoclonal CD3 antibody for stable remission of new-onset diabetes in mice(2014)
Authors: Lei Ding, Conny Gysemans, Geert M Stangé, Yves Heremans, Yixing Yuchi, Tatiana Takiishi, H. Korf, Marie Chintinne, Richard Carr, Henry Heimberg, et al.
Pages: 1-13 - Partial duct ligation: β-cell proliferation and beyond(2014)
Authors: Mark Van de Casteele, Gunter Leuckx, Ying Cai, Yixing Yuchi, Violette Coppens, Sofie De Groef, Naomi Van Gassen, L Baeyens, Yves Heremans, Christopher V E Wright, et al.
Pages: 2567-2577 - Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells(2014)
Authors: Massimiliano Paganelli, Omar Nyabi, Brice Sid, Jonathan Evraerts, Imane El Malmi, Yves Heremans, Laurent Dolle, Carley Benton, Pedro-Buc Calderon, Leo A van Grunsven, et al.
Pages: 1377-1391 - Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes(2014)
Authors: Nico De Leu, Yves Heremans, Violette Coppens, Naomi Van Gassen, Ying Cai, Joke D'Hoker, Judith Magenheim, Seth Salpeter, Avital Swisa, Abed Khalaileh, et al.
Pages: 140-147