Researcher
Heleen Dewitte
- Keywords:cancer vaccination, microbubbles, tumor micro-environment, ultrasound, gene delivery, cancer immunotherapy, nanovaccine, Nanomedicine, drug delivery
- Disciplines:Adaptive immunology, Gene and molecular therapy, Vaccinology, Inflammation, Innate immunity, Cancer therapy, Drug discovery and development not elsewhere classified, Biopharmaceuticals, In vitro testing, Non-clinical studies, Nanobiotechnology, Medical nanotechnology, Cancer biology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2010 → 20 Dec 2020
Projects
1 - 6 of 6
- Fonds Catharina Weekers: "Expanding the immune army: Combatting multiple myeloma using a rational combination of Galsome nanovaccines and immune checkpoint inhibition"From1 Jul 2020 → 30 Jun 2023Funding: Foundations, funds and other with scientific goal
- Further development of mRNA Galsomes as nanovaccines for cancer immunotherapy: combination with checkpoint inhibition and translation to the clinic.From1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Combatting multiple myeloma using Galsome immunotherapyFrom1 Oct 2019 → 20 Dec 2020Funding: BOF - postdoctoral mandates
- Mechanical high intensity focused ultrasound (mHIFU): exploring the synergistic effects between killing tumor cells and inducing antitumor immunity in vivo.From1 Jan 2019 → 31 Dec 2019Funding: FWO research grant KAN
- Exploring ultrasound mediated mRNA transfection of lymph nodes and ultrasound-induced tumor ablation as a synergistic anticancer strategy.From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
- The use of mRNA-lipoplex loaded microbubbles in cancer vaccination (grant Heleen Dewitte)From1 Oct 2010 → 5 Jan 2016Funding: IWT personal funding - specialisation scholarships
Publications
11 - 20 of 34
- Non-viral delivery of chemically modified mRNA to the retina : subretinal versus intravitreal administration(2019)
Authors: Joke Devoldere, Karen Peynshaert, Heleen Dewitte, Christian Vanhove, Lies De Groef, Lieve Moons, Sinem Yilmaz Özcan, Deniz Dalkara, Katrien Remaut
Pages: 315 - 330 - The obstacle course to the inner retina : hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane(2019)
Authors: Joke Devoldere, Mike Wels, Karen Peynshaert, Heleen Dewitte, Katrien Remaut
Pages: 161 - 171 - Sonoprinting of nanoparticle-loaded microbubbles : unraveling the multi-timescale mechanism(2019)
Authors: Silke Roovers, Guillaume Lajoinie, Ine De Cock, Toon Brans, Heleen Dewitte, Kevin Braeckmans, Michel Versuis, Stefaan De Smedt, Ine Lentacker
- Enhancing nucleic acid delivery with ultrasound and microbubbles(2019)Edition: 2nd ed.Series: Methods in Molecular Biology
Authors: Heleen Dewitte, Silke Roovers, Stefaan De Smedt, Ine Lentacker, Manfred Ogris, Haider Sami
Pages: 241 - 251 - Non-spherical oscillations drive the ultrasound-mediated release from targeted microbubbles(2018)
Authors: Guillaume Lajoinie, Ying Luan, Erik Gelderblom, Benjamin Dollet, Frits Mastik, Heleen Dewitte, Ine Lentacker, Nico de Jong, Michel Versluis
- Optimized messenger RNA immunolipoplexes for cancer immunotherapy : balancing immunogenicity and adjuvancy(2018)
Authors: Rein Verbeke, Ine Lentacker, Karine Breckpot, Heleen Dewitte
Number of pages: 1 - Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy(2018)
Authors: Elisa Zagato, Lotte Vermeulen, Heleen Dewitte, Griet Van Imschoot, Kristiaan Neyts, Katrien Remaut, Kevin Braeckmans
Pages: 1142 - 1149 - mRNA-based nanoparticles for therapeutic cancer vaccination(2017)
Authors: Rein Verbeke, Laura Wayteck, Karine Breckpot, Christian Vanhove, Benedicte Descamps, Heleen Dewitte, Ine Lentacker
Number of pages: 1 - Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy : restoring the immunogenicity of immunosilent mRNA(2017)
Authors: Rein Verbeke, Ine Lentacker, Laura Wayteck, Karine Breckpot, Mieke Van Bockstal, Benedicte Descamps, Christian Vanhove, Heleen Dewitte
Pages: 287 - 300 - Hitchhiking nanoparticles: reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes(2016)
Authors: Laura Wayteck, Heleen Dewitte, Lynn De Backer, Karine Breckpot, Koen Raemdonck
Pages: 243 - 254
Patents
1 - 2 of 2