Researcher
Heleen Dewitte
- Keywords:cancer vaccination, microbubbles, tumor micro-environment, ultrasound, gene delivery, cancer immunotherapy, nanovaccine, Nanomedicine, drug delivery
- Disciplines:Adaptive immunology, Gene and molecular therapy, Vaccinology, Inflammation, Innate immunity, Cancer therapy , Drug discovery and development not elsewhere classified, Biopharmaceuticals, In vitro testing, Non-clinical studies, Nanobiotechnology, Medical nanotechnology, Cancer biology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2010 → 20 Dec 2020
Projects
1 - 5 of 5
- Further development of mRNA Galsomes as nanovaccines for cancer immunotherapy: combination with checkpoint inhibition and translation to the clinic.From1 Nov 2019 → TodayFunding: FWO Strategic Basic Research Grant
- Combatting multiple myeloma using Galsome immunotherapyFrom1 Oct 2019 → 20 Dec 2020Funding: BOF - postdoctoral mandates
- Mechanical high intensity focused ultrasound (mHIFU): exploring the synergistic effects between killing tumor cells and inducing antitumor immunity in vivo.From1 Jan 2019 → 31 Dec 2019Funding: FWO research grant KAN
- Exploring ultrasound mediated mRNA transfection of lymph nodes and ultrasound-induced tumor ablation as a synergistic anticancer strategy.From1 Oct 2015 → 30 Sep 2019Funding: FWO fellowships
- The use of mRNA-lipoplex loaded microbubbles in cancer vaccination (grant Heleen Dewitte)From1 Oct 2010 → 5 Jan 2016Funding: IWT personal funding - specialisation scholarships
Publications
1 - 10 of 32
- Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model(2022)
Authors: Joke Deprez, Silke Roovers, Guillaume Lajoinie, Heleen Dewitte, Tine Decruy, Julie Coudenys, Benedicte Descamps, Christian Vanhove, Michel Versluis, Dirk Elewaut, et al.
- Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo(2021)
Authors: Jelter Van Hoeck, Thijs Van de Vyver, Aranit Harizaj, Glenn Goetgeluk, Pieterjan Merckx, Jing Liu, Mike Wels, Félix Sauvage, Herlinde De Keersmaecker, Christian Vanhove, et al.
- The dawn of mRNA vaccines : the COVID-19 case(2021)
Authors: Rein Verbeke, Sabine Lentacker, Stefaan De Smedt, Heleen Dewitte
Pages: 511 - 520 - mRNA in cancer immunotherapy : beyond a source of antigen(2021)
Authors: Lien Van Hoecke, Rein Verbeke, Heleen Dewitte, Sabine Lentacker, Karim Vermaelen, Karine Breckpot, Sandra Van Lint
- mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice(2020)
Authors: Lien Van Hoecke, Rein Verbeke, Dorien De Vlieger, Heleen Dewitte, Kenny Roose, Sharon Van Nevel, Olga Krysko, Claus Bachert, Bert Schepens, Sabine Lentacker, et al.
Pages: 777 - 787 - Ultrasound-responsive cavitation nuclei for therapy and drug delivery(2020)
Authors: Klazina Kooiman, Silke Roovers, Simone A. G. Langeveld, Robert T. Kleven, Heleen Dewitte, Meaghan A. O'Reilly, Jean-Michel Escoffre, Ayache Bouakaz, Martin D. Verweij, Kullervo Hynynen, et al.
Pages: 1296 - 1325 - The obstacle course to the inner retina : hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane(2019)
Authors: Joke Devoldere, Mike Wels, Karen Peynshaert, Heleen Dewitte, Stefaan De Smedt, Katrien Remaut
Pages: 161 - 171 - Sonoprinting of nanoparticle-loaded microbubbles : unraveling the multi-timescale mechanism(2019)
Authors: Silke Roovers, Guillaume Lajoinie, Ine De Cock, Toon Brans, Heleen Dewitte, Kevin Braeckmans, Michel Versuis, Stefaan De Smedt, Sabine Lentacker
- Three decades of messenger RNA vaccine development(2019)
Authors: Rein Verbeke, Sabine Lentacker, Stefaan De Smedt, Heleen Dewitte
- Broadening the message : a nanovaccine co-loaded with messenger RNA and U+03B1-GalCer induces antitumor immunity through conventional and natural killer T cells(2019)
Authors: Rein Verbeke, Sabine Lentacker, Karine Breckpot, Jonas Janssens, Serge Van Calenbergh, Stefaan De Smedt, Heleen Dewitte
Pages: 1655 - 1669