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Researcher
Graciela Andrei
- Disciplines:Virology
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 15
- Viral Oncology: molecular biology and pathogenesis of post-transplant lymphoproliferative disorder (PTLD)From13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Dynamics of cytomegalovirus infection: evolution towards antiviral drug resistanceFrom1 Feb 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → 30 Apr 2024Funding: FWO Medium Size Research Infrastructure
- Challenges and opportunities in the management of herpes simplex virus antiviral resistanceFrom17 Apr 2018 → 17 May 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Unraveling the role of BK polyomavirus variants and of cellular CMP kinase on viral pathogenicity and clearance in renal-transplant patientsFrom1 Oct 2017 → 30 Sep 2021Funding: FWO Applied Biomedical Research (TBM)
- Automated real-time quantitative live cell analysisFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- MERKEL CELL CARCINOMA, TOWARDS THE IDENTIFICATION OF NOVEL MOLECULAR TARGETS AND THE ESTABLISHMENT OF A THREE-DIMENSIONAL CELL CULTURE MODELFrom9 Nov 2015 → 14 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding gamma-herpesvirus pathogenesis and development of novel treatment strategies.From1 Aug 2014 → 3 Dec 2020Funding: FWO Strategic Basic Research Grant
- An automated platform for multiparameter data collection on live pathogens of higher or unknown biosafety risk.From26 Jun 2014 → 31 Dec 2018Funding: Hercules - Large scale research infrastructure
Publications
1 - 10 of 248
- CRISPR/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1 isolate identifies F289S as novel acyclovir-resistant mutation(2024)
Authors: Robert Snoeck, Graciela Andrei
- Treatment of Epstein-Barr Virus infection in immunocompromised patients(2024)
Authors: Martyna Pociupany, Robert Snoeck, Graciela Andrei
- Challenges and opportunities in the management of herpes simplex virus antiviral resistance(2024)
Authors: Hanna Schalkwijk, Robert Snoeck, Graciela Andrei
- Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl] Z )-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl] phosphonic acid prodrug with pronounced antiviral activity against DNA viruses(2024)
Authors: Robert Snoeck, Graciela Andrei
- Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1(2024)
Authors: Hanna Schalkwijk, Neesha Rajesh Shewakramani, Kalyan Das, Graciela Andrei, Robert Snoeck
- Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization(2024)
Authors: Robert Snoeck, Graciela Andrei
- A Herpes Simplex Virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in a Patient With Immunodeficiency and Confirmed by Gene Editing(2023)
Authors: Hanna Schalkwijk, Graciela Andrei, Robert Snoeck
Pages: 1505 - 1515 - An observational cohort study of histological screening for BK polyomavirus nephropathy following viral replication in plasma(2023)
Authors: Evert Cleenders, Elisabet Van Loon, Katrien Lagrou, Graciela Andrei, Katrien De Vusser, Dirk Kuypers, Olga Mineeva-Sangwo, Robert Snoeck, Marc Van Ranst, Geert Verbeke, et al.
Pages: 1018 - 1034 - Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development(2023)
Authors: Graciela Andrei, Robert Snoeck
Pages: 719 - 739 - Phenotypic Test of Benzo[4,5]imidazo[1,2-c]pyrimidinone-Based Nucleoside and Non-Nucleoside Derivatives against DNA and RNA Viruses, Including Coronaviruses(2023)
Authors: Robert Snoeck, Graciela Andrei
Patents
1 - 6 of 6
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Novel purine derivatives and drugs comprising same (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)