Researcher
Georges Leclercq
- Keywords:human, function, NK cells, differentiation, transcription factors
- Disciplines:Adaptive immunology, Applied immunology, Autoimmunity, Immunogenetics, Innate immunity, Hematology
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → 28 Feb 2023 - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 7 of 7
- Strengthening the UGent patent position on an improved cultivation method for adoptive cell therapies (immuno-oncology).From1 Apr 2019 → 31 Mar 2020Funding: IOF - technology concept exploration
- Innate lymphoid cells in multiple sclerosis: implications of genetic risk variantsFrom1 Jan 2018 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
- Transcriptional regulation of differentiation of human natural killer and innate lymphoid cells.From1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- A new mechanism of tumor escape from innate-like T lymphocytesFrom1 Jan 2015 → 31 Dec 2018Funding: Foundations, funds and other with scientific goal
- The role of the transcription factors Ets-1, E4BP4 and GATA-3 in the development of human natural killer cells.From1 Oct 2012 → 1 Oct 2014Funding: BOF - Other initiatives
- Yellow/Green laser upgrade for LSRII analyser and FACSARIAII sorter flow cytometersFrom15 Jun 2012 → 30 Jun 2016Funding: BOF - Other initiatives
- A flow cytometer to perform multiparameter sorting, including single-cell deposition under biohazard conditions L2From1 Jan 2009 → 31 Dec 2010Funding: BOF - Other initiatives
Publications
11 - 20 of 79
- In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality(2021)
Authors: Sarah Bonte, Stijn De Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz De Cock, Karin Weening, Tom Taghon, et al.
- A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair(2021)
Authors: Steven Strubbe, Marieke De Bruyne, Ulrich Pannicke, Elien Beyls, Bart Vandekerckhove, Georges Leclercq, Elfride De Baere, Victoria Bordon, Anne Vral, Klaus Schwarz, et al.
- Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty(2020)
Authors: Marieke Lavaert, Bart Vandekerckhove, Georges Leclercq, Kai Ling Liang, Tom Taghon
- Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development(2020)
Authors: Anna Kuchmiy, Matthias De Decker, Steven Strubbe, Marieke Lavaert, Georges Leclercq, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon
Pages: 1280 - 1292 - The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation(2020)
Authors: Sylvie Taveirne, Sigrid Wahlen, Wouter Van Loocke, Els Van Ammel, Katrien De Mulder, Laurentijn Tilleman, Marc Aumercier, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, et al.
Pages: 288 - 298 - Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage(2020)
Authors: Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, et al.
- T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources(2020)
Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
- Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development(2020)
Authors: Anne-Catherine Dolens, Kaat Durinck, Marieke Lavaert, Joni Van der Meulen, Imke Velghe, Jelle De Medts, Karin Weening, Juliette Roels, Katrien De Mulder, Pieter-Jan Volders, et al.
- Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes(2020)
Authors: Marieke Lavaert, Niels Vandamme, Jong-Eun Park, Monica S. Kowalczyk, Bo Li, Orr Ashenberg, Marcin Tabaka, Danielle Dionne, Timothy L. Tickle, Michal Slyper, et al.
Pages: 1088 - 1104.e6 - Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly(2020)
Authors: Stijn De Munter, Alexander Van Parys, Layla Bral, Joline Ingels, Glenn Goetgeluk, Sarah Bonte, Melissa Pille, Lore Billiet, Karin Weening, Annick Verhee, et al.
Patents
1 - 2 of 2
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)