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Researcher
Georg Halder
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Cancer biology
- Disciplines (KU Leuven):Morphological sciences, Oncology
- See also: Georg Halder (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Growth Control and Cancer Research (VIB-KU Leuven) (Division)
Responsible
From1 Jan 2017 → Today - Laboratory of Growth Control and Cancer Research (VIB-KU Leuven) (Division)
Member
From1 Jan 2017 → Today - Halder Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 May 2012 → 31 Dec 2016
Projects
11 - 20 of 39
- Synthetic organogenesis: the role of blood vessels in orchestrating the development andmorphogenesis of ectopic miniorgans.From1 Jan 2021 → TodayFunding: BOF - iBOF
- Discovering a novel anti-cancer strategy: Inhibiting INF2 to specifically kill cancer cellsFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding how fatty liver disease reprograms liver cancer cellsFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- To understand and suppress liver cancer cell plasticity and evolutionFrom1 Oct 2020 → TodayFunding: BOF - projects
- To understand and suppress liver/pancreas cancer cell plasticity and evolutionFrom15 Sep 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Studying the contribution of an underlying liver disease to the development and progression of liver cancer: from NASH to HCCFrom6 Aug 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting the Hippo pathway for cancer therapy: Discovering endogenous tumor suppressor mechanismsFrom29 Oct 2018 → 1 Mar 2024Funding: FWO fellowships
- Characterizing a novel anti-cancer mechanism against human cancer cells in mouse models for chronic liver diseaseFrom1 Oct 2018 → 30 Sep 2021Funding: FWO fellowships
- The Hippo Pathway in Liver Cancer HeterogeneityFrom11 Jun 2018 → 11 Jun 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Function of the Hippo Pathway in Organ Growth Control and RegenerationFrom8 Jan 2018 → 31 Oct 2023Funding: FWO fellowships
Publications
1 - 10 of 58
- Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer.(2024)
Authors: Georg Halder
Pages: 2700 - The Cell Competition Theory of Cancer(2024)
Authors: Ana Algueró Nadal, Georg Halder
- Cell competition induced by relative differences in levels of Yap/Taz causes lethal autophagy in liver cancer.(2024)
Authors: Soheil Soheily, Georg Halder
- Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation(2024)
Authors: Roel Vandepoel, Valerie Christiaens, Jonas Demeulemeester, David Mauduit, Georg Halder, Stein Aerts
- A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models.(2023)
Authors: Hanne Hillen, Weronika Kowalczyk, Patrick Chaltin, Georg Halder
Pages: OF1 - OF11 - Shared enhancer gene regulatory networks between wound and oncogenic programs(2023)
Authors: Seppe De Winter, Georg Halder, Stein Aerts
- SW-682: A novel TEAD inhibitor for the treatment of cancers bearing mutations in the Hippo signaling pathway(2023)
Authors: Georg Halder
- In vivo effects of novel YAP/TAZ-TEAD inhibitors(2023)
Authors: Hanne Hillen, Georg Halder
- Reverse engineering cellular identity at single-cell resolution(2023)
Authors: Carmen Bravo González-Blas, Stein Aerts, Georg Halder
- Hippo signaling instructs ectopic but not normal organ growth(2022)
Authors: Weronika Kowalczyk, Hanne Hillen, Jun Xie, Soheil Soheily, Ivan Moya, Stein Aerts, Georg Halder
Pages: 744 - +
Patents
1 - 2 of 2