Researcher
Geert Berx
- Keywords:Metastasis, Cancer, EMT
- Disciplines:Transcription and translation, Cancer therapy, Cellular interactions and extracellular matrix, Cell movement, Cell signalling, Epigenetics, Genetics, Cancer biology
Affiliations
- Department of Biomedical molecular biology (Department)
Member
From1 Jan 1996 → Today - Department of Plant Biotechnology and Bioinformatics (Department)
Member
From1 Feb 1993 → 31 Dec 1995
Projects
1 - 10 of 21
- Unraveling the molecular regulation of ZEB driven melanoma plasticity as a basis for anti-melanoma therapyFrom1 Nov 2023 → TodayFunding: FWO Strategic Basic Research Grant
- Dissecting stromal-cancer cell interactions at the perivascular niche to detect and intercept the early metastatic process.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Unbiased exploration of epithelial-mesenchymal plasticity in colorectal cancer reveals role for non-canonical STAT1 signallingFrom1 Nov 2022 → TodayFunding: FWO fellowships
- A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapiesFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- An alternative more tolerable L-asparaginase variant for the treatment of metastatic breast cancerFrom1 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- The use of a less toxic alternative asparaginase variant to treat metastatic breast cancerFrom1 Oct 2021 → TodayFunding: BOF - projects
- Defining the role of ZEB1 in tumour initiation and progression of basal-like breast cancerFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the Tumor Microenvironment in Colorectal Peritoneal MetastasesFrom1 Jan 2021 → TodayFunding: BOF - projects
- The peritoneal microenvironment in the pathogenesis of colorectal peritoneal carcinomatosis: the role of MMT and cancer-associated fibroblastsFrom1 Nov 2020 → TodayFunding: FWO fellowships
Publications
1 - 10 of 43
- Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics(2024)
Authors: Jana Ramon, Yanou Engelen, Herlinde De Keersmaecker, Ilia Goemaere, Deep Punj, Julián Mejía Morales, Cédric Bonte, Geert Berx, Esther Hoste, Stephan Stremersch, et al.
Pages: 1019 - 1036 - A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer(2023)
Authors: Jeroen Verstappe, Geert Berx
Pages: 15 - 28 - The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation(2023)
Authors: Jef Haerinck, Steven Goossens, Geert Berx
Pages: 590 - 609 - Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1(2022)
Authors: Yingying Han, Alvaro Villarreal-Ponce, Guadalupe Gutierrez, Quy Nguyen, Peng Sun, Ting Wu, Benjamin Sui, Geert Berx, Thomas Brabletz, Kai Kessenbrock, et al.
- Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells(2021)
Authors: Maria Lasierra Losada, Melissa Pauler, Niels Vandamme, Steven Goossens, Geert Berx, Moritz Leppkes, Harald Schuhwerk, Simone Brabletz, Thomas Brabletz, Marc P. Stemmler
- The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer(2021)
Authors: Rahul Sreekumar, Hajir Al-Saihati, Muhammad Emaduddin, Karwan Moutasim, Massimiliano Mellone, Ashish Patel, Seval Kilic, Metin Cetin, Sule Erdemir, Marta Salgado Navio, et al.
Pages: 2065 - 2083 - Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity(2021)
Authors: Jueqiong Wang, Carlos Farkas, Aissa Benyoucef, Catherine Carmichael, Katharina Haigh, Nick Wong, Danny Huylebroeck, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, et al.
- Partial EMT takes the lead in cancer metastasis(2021)
Authors: Jef Haerinck, Geert Berx
Pages: 3174 - 3176 - The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma(2021)
Authors: Manuel Ruh, Marc P. Stemmler, Isabell Frisch, Kathrin Fuchs, Ruthger Roey, Julia Kleemann, Maike Roas, Harald Schuhwerk, Rebecca L. Eccles, Abbas Agaimy, et al.
Pages: 199 - 211 - Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma(2020)
Authors: Elien De Thaye, Koen Van de Vijver, Joni Van der Meulen, Joachim Taminau, Glenn Wagemans, Hannelore Denys, Jo Van Dorpe, Geert Berx, Wim Ceelen, Jan Van Bocxlaer, et al.