Researcher
Frederik De Smet
- Disciplines:Macromolecular and materials chemistry, Laboratory medicine, Morphological sciences
Affiliations
- Translational Cell & Tissue Research (Division)
Member
From1 Oct 2016 → Today - Switch Laboratory (VIB-KU Leuven) (Division)
Member
From1 Jan 2011 → 30 Sep 2016 - Centre for Molecular and Vascular Biology (Division)
Member
From15 Nov 2003 → 30 Sep 2005
Projects
1 - 10 of 47
- Virtual StainingFrom15 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The malignant Glioma immuno-oncology matchmaker: towards data-driven precision medicine using spatially resolved radio-multiomicsFrom1 Jan 2024 → TodayFunding: HORIZON.2.1 - Health
- Mapping epigenetic regulatory pathways that drive Glioblastoma plasticity at single-cell resolutionFrom13 Nov 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding the RNA regulatory interactome landscape of radiation response in glioblastomaFrom13 Oct 2023 → TodayFunding: SCK (Study Centre Nuclear Energy)
- PEGASuS - PEdiatric Glioma Architecture Single cell and Spatial mapping: in search for effectors of radioresistanceFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Mapping the therapeutic potential of AG5 and its effects on TME using a multi-omics approach in IDHwt GBM patient-derived models.From1 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A platform for advanced single-cell pathological profiling of immune-brain interactionsFrom15 Jun 2023 → TodayFunding: BOF - various
- Immunotherapy for childhood, adolescent, and adult Glioblastoma: towards tumour-immune interactions driven precision medicine using spatially resolved radio-multiomics.From15 Jan 2023 → TodayFunding: BOF - various
- Targeting radiation-induced plasticity in Glioblastoma: from fundamental insights to tailored therapeutic opportunitiesFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Unique IsoPlexis technology for multiplexed single cell functional profilingFrom1 Jan 2023 → TodayFunding: BOF - scientific equipment program
Publications
11 - 20 of 67
- Capturing age-related changes in the tumor microenvironment of luminal breast cancer using the multiplex immunohistochemistry technique, MILAN.(2023)
Authors: Yentl Lambrechts, Maxim De Schepper, Tatjana Geukens, Hanne Vos, Julie Messiaen, Patrick Neven, Christine Desmedt, Francesca Bosisio, Frederik De Smet, Sigrid Hatse, et al.
- Single‐cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma(2023)
Authors: Dena Panovska, Lien Solie, Francesca Bosisio, Paul Clement, Raf Sciot, Steven De Vleeschouwer, Frederik De Smet
- Cellular and molecular features related to exceptional therapy response and extreme long-term survival in glioblastoma(2023)
Authors: Maxime Vanmechelen, Paul Clement, Jean-françois Daisne, Isabelle Vanden Bempt, Raf Sciot, Abhishek Garg, Patrizia Agostinis, Frederik De Smet, Steven De Vleeschouwer
Pages: 11107 - 11126 - Multiomics and spatial mapping characterizes human CD8+T cell states in cancer(2023)
Authors: Stefan Naulaerts, Daniel Borras Morales, Julie Messiaen, Isaure Vanmeerbeek, Jenny Sprooten, Dena Panovska, Yannick Van Herck, Lendert Gelens, Tom Venken, Oliver Bechter, et al.
- ALK amplification and rearrangements are recurrent targetable events in congenital and adult glioblastoma(2023)
Authors: Frederik De Smet
- Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation(2023)
Authors: Filip Claes, Rob van der Kant, Mark Fiers, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
- Patient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivity(2023)
Authors: Maxime Vanmechelen, Kim Kampen, Frederik De Smet
- A MULTI-OMIC, FUNCTIONAL PRECISION ONCOLOGY METHOD TO IDENTIFY RESPONSIVE GLIOBLASTOMA TUMOR CELLS AT SINGLE CELL RESOLUTION(2022)
Authors: Yanti De Visser, Dena Panovska, Steven De Vleeschouwer, Lien Solie, Paul Clement, Raf Sciot, Frederik De Smet
Pages: 7 - 7 - Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates(2022)
Authors: Kourosh Ahmadzadeh, Bram Boeckx, Amber De Visscher, Eline Bernaerts, Pierre Van Mol, Yannick Van Herck, Greet Hermans, Alexander Wilmer, Mieke Gouwy, Abhishek Garg, et al.
- Generation of patient-derived models from a metastatic pediatric diffuse leptomeningeal glioneuronal tumor with KIAA1549::BRAF fusion(2022)
Authors: Julie Messiaen, Lien Spans, Anne Uyttebroeck, Bart Depreitere, Isabelle Vanden Bempt, Raf Sciot, Frederik De Smet
Pages: 793 - 797
Patents
1 - 5 of 5
- Means and methods for generating improved proteins (Inventor)
- Means and methods for generating improved proteins (Inventor)
- Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor (Inventor)
- Methods for screening inhibitors of tumor associated protein aggregation (Inventor)
- Methods for screening inhibitors of tumour associated protein aggregation. (Inventor)