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Researcher
Fred Van Leuven
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Sep 2014
Projects
1 - 9 of 9
- Influence of chronic oligemia on neurovascular defects and their relation to the onset and development of neurodegeneration: in vivo evaluation of neurovascular response capacity and metabolism in an Alzheimer mouse model.From1 Oct 2013 → 17 Sep 2019Funding: FWO fellowships
- Mechanisms underlying protein tau-mediated neurodegeneration: combining transgenic mouse models and AAV vectors.From1 Oct 2010 → 30 Sep 2014Funding: BOF - Concerted Research Project from 1994
- Differential analysis of the physiological functions of GSK-3a/b isozymes in brain in vivo.From1 Oct 2009 → 30 Jun 2010Funding: BOF - Other initiatives
- Development and validation of active and passive immunotherapy targeted at protein Tau in transgenic mouse models for Alzheimer's diseaseFrom1 Oct 2008 → 13 Sep 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Tau-based Mabs and Vaccines: development and pre-clinical assessment of diagnostic and therapeutic potential in transgenic models for Tauopathy & Alzheimer's disease.From1 Oct 2008 → 30 Sep 2012Funding: IOF - Industrial Research Fund
- NEURO.GSK3: GSK3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment.From1 Oct 2008 → 31 Dec 2011Funding: Health
- The physiological and pathological contribution of GSK3 isozymes in normal mice and transgenic Alzheimer mice models.From1 Sep 2008 → 1 Jan 2010Funding: Own budget, for example: patrimony, inscription fees, gifts
- Inter-relations of protein Tau, GSK3 and Nectin-3 in synaptic structure and plasticity in the hippocampus of mouse models for Alzheimer's diseaseFrom1 Feb 2008 → 28 Jun 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Analysis of adaptations of cytoskeleton, dendritic spines and synaptic plasticity in relation to physiological and pathological phosphorylation of protein tau in vivo.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project
Publications
71 - 80 of 86
- Decreased expression of multidrug efflux transporters in the brains of GSK-3beta transgenic mice(2009)
Authors: Fred Van Leuven
Pages: 1 - 10 - 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease(2009)
Authors: Kim Serdons, Fred Van Leuven, Guy Bormans, Alfons Verbruggen
Pages: 1415 - 1426 - Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice(2009)
Authors: Maarten Gysemans, Fred Van Leuven
Pages: 241 - 256 - Synthesis of 18F-labelled 2-(4'-fluorophenyl)-1,3-benzothiazole and evaluation as amyloid imaging agent in comparison with [11C]PIB(2009)
Authors: Kim Serdons, Fred Van Leuven, Koen Van Laere, Guy Bormans, Alfons Verbruggen
Pages: 602 - 605 - Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels(2009)
Authors: Fred Van Leuven
Pages: 319 - 29 - Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis(2008)
Authors: Dietmar Thal, Bart De Strooper, Fred Van Leuven
Pages: 12097 - 12106 - Neurogenesis in relation to aging and dementia(2008)
Authors: Fred Van Leuven
Pages: S178 - S178 - Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson(2008)
Authors: Piotr Zabrocki, Klaartje Pellens, Fred Van Leuven, Joris Winderickx
Pages: 1767 - 1780 - Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1(2008)
Authors: Thomas Voets, Bernd Nilius, Fred Van Leuven
Pages: 639 - 652 - Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo(2008)
Authors: Fred Van Leuven
Pages: 186 - 189
Patents
1 - 10 of 10
- Humanized tau antibody (Inventor)
- Pharmaceutical composition (Inventor)
- Methods of diagnosing diseases caused by or associated with neurofibrillary tangles by phosphospecific antibodies recognising tau (Inventor)
- Antibodies to phosphorylated tau aggregates (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)
- Methods of diagnosing tau-protein-associated disease (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)
- ANTIBODIES RECOGNISING PHOSPHO-TAU (Inventor)
- Pharmaceutical composition (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)