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Researcher
Fred Van Leuven
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Sep 2014
Projects
1 - 9 of 9
- Influence of chronic oligemia on neurovascular defects and their relation to the onset and development of neurodegeneration: in vivo evaluation of neurovascular response capacity and metabolism in an Alzheimer mouse model.From1 Oct 2013 → 17 Sep 2019Funding: FWO fellowships
- Mechanisms underlying protein tau-mediated neurodegeneration: combining transgenic mouse models and AAV vectors.From1 Oct 2010 → 30 Sep 2014Funding: BOF - Concerted Research Project from 1994
- Differential analysis of the physiological functions of GSK-3a/b isozymes in brain in vivo.From1 Oct 2009 → 30 Jun 2010Funding: BOF - Other initiatives
- Development and validation of active and passive immunotherapy targeted at protein Tau in transgenic mouse models for Alzheimer's diseaseFrom1 Oct 2008 → 13 Sep 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Tau-based Mabs and Vaccines: development and pre-clinical assessment of diagnostic and therapeutic potential in transgenic models for Tauopathy & Alzheimer's disease.From1 Oct 2008 → 30 Sep 2012Funding: IOF - Industrial Research Fund
- NEURO.GSK3: GSK3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment.From1 Oct 2008 → 31 Dec 2011Funding: Health
- The physiological and pathological contribution of GSK3 isozymes in normal mice and transgenic Alzheimer mice models.From1 Sep 2008 → 1 Jan 2010Funding: Own budget, for example: patrimony, inscription fees, gifts
- Inter-relations of protein Tau, GSK3 and Nectin-3 in synaptic structure and plasticity in the hippocampus of mouse models for Alzheimer's diseaseFrom1 Feb 2008 → 28 Jun 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Analysis of adaptations of cytoskeleton, dendritic spines and synaptic plasticity in relation to physiological and pathological phosphorylation of protein tau in vivo.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project
Publications
21 - 30 of 86
- Early markers of tau pathology in young Tau.P301L mice: synaptic plasticity, cognition and neuronal synchrony(2016)
Authors: A Latif-Hernandez, An Schreurs, Tariq Ahmed, Disha Shah, Fred Van Leuven, A Van der Linden, Rudi D'Hooge, Detlef Balschun
Pages: 415 - 415 - Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice(2015)
Authors: Lawrence Van Helleputte, Tom Dresselaers, Kristof Govaerts, Uwe Himmelreich, Fred Van Leuven, Ludo Van Den Bosch, James Dooley, Stephanie Humblet-Baron, Adrian Liston
Pages: 125 - 32 - Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin(2015)
Authors: Fred Van Leuven
Pages: 482 - 489 - Glycogen synthase kinase-3 regulates synaptic Matrix Metaloproteinase-9(2014)
Authors: Fred Van Leuven
Pages: 375 - 375 - Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β(2014)
Authors: Fred Van Leuven
Pages: 2442 - 2453 - Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L x GSK3β mice by delaying brainstem tauopathy(2014)
Authors: Fred Van Leuven
Pages: 119 - 132 - Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease(2014)
Authors: Fred Van Leuven
- Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy(2014)
Authors: Geert Callewaert, Fred Van Leuven
- Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis(2014)
Authors: Fred Van Leuven
Pages: 78 - 91 - Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice(2013)
Authors: Fred Van Leuven
Patents
1 - 10 of 10
- Humanized tau antibody (Inventor)
- Pharmaceutical composition (Inventor)
- Methods of diagnosing diseases caused by or associated with neurofibrillary tangles by phosphospecific antibodies recognising tau (Inventor)
- Antibodies to phosphorylated tau aggregates (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)
- Methods of diagnosing tau-protein-associated disease (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)
- ANTIBODIES RECOGNISING PHOSPHO-TAU (Inventor)
- Pharmaceutical composition (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)