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Researcher
Fred Van Leuven
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Department of Human Genetics (Department)
Member
From1 Oct 1999 → 30 Sep 2014
Projects
1 - 9 of 9
- Influence of chronic oligemia on neurovascular defects and their relation to the onset and development of neurodegeneration: in vivo evaluation of neurovascular response capacity and metabolism in an Alzheimer mouse model.From1 Oct 2013 → 17 Sep 2019Funding: FWO fellowships
- Mechanisms underlying protein tau-mediated neurodegeneration: combining transgenic mouse models and AAV vectors.From1 Oct 2010 → 30 Sep 2014Funding: BOF - Concerted Research Project from 1994
- Differential analysis of the physiological functions of GSK-3a/b isozymes in brain in vivo.From1 Oct 2009 → 30 Jun 2010Funding: BOF - Other initiatives
- Development and validation of active and passive immunotherapy targeted at protein Tau in transgenic mouse models for Alzheimer's diseaseFrom1 Oct 2008 → 13 Sep 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Tau-based Mabs and Vaccines: development and pre-clinical assessment of diagnostic and therapeutic potential in transgenic models for Tauopathy & Alzheimer's disease.From1 Oct 2008 → 30 Sep 2012Funding: IOF - Industrial Research Fund
- NEURO.GSK3: GSK3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment.From1 Oct 2008 → 31 Dec 2011Funding: Health
- The physiological and pathological contribution of GSK3 isozymes in normal mice and transgenic Alzheimer mice models.From1 Sep 2008 → 1 Jan 2010Funding: Own budget, for example: patrimony, inscription fees, gifts
- Inter-relations of protein Tau, GSK3 and Nectin-3 in synaptic structure and plasticity in the hippocampus of mouse models for Alzheimer's diseaseFrom1 Feb 2008 → 28 Jun 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Analysis of adaptations of cytoskeleton, dendritic spines and synaptic plasticity in relation to physiological and pathological phosphorylation of protein tau in vivo.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project
Publications
11 - 20 of 86
- Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy(2018)
Authors: Fred Van Leuven
Pages: 173 - 180 - GSK3β Controls mTOR and Prosurvival Signaling in Neurons(2018)
Authors: Fred Van Leuven
Pages: 6050 - 6062 - NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology(2017)
Authors: Fred Van Leuven
Pages: 444 - 451 - GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology(2017)
Authors: Fred Van Leuven
Pages: 200 - 211 - Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope(2017)
Authors: Fred Van Leuven
Pages: 585 - 599 - Mild Traumatic Brain Injury of Tau.P301L Mice Results in an Impairment of Neural Plasticity(2016)
Authors: Tariq Ahmed, An Schreurs, Fred Van Leuven
- Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease(2016)
Authors: Fred Van Leuven
Pages: 39118 - 39135 - Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models(2016)
Authors: Fred Van Leuven
Pages: 792 - 798 - Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-beta Precursor Protein (vol 32, pg 4410, 2012)(2016)
Authors: Callum Parr, Raffaela Carzaniga, Steve M Gentleman, Fred Van Leuven, Jochen Walter, Magdalena Sastre
Pages: 1219 - 1219 - Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes(2016)
Authors: Fred Van Leuven
Pages: 1902 - 1916
Patents
1 - 10 of 10
- Humanized tau antibody (Inventor)
- Pharmaceutical composition (Inventor)
- Methods of diagnosing diseases caused by or associated with neurofibrillary tangles by phosphospecific antibodies recognising tau (Inventor)
- Antibodies to phosphorylated tau aggregates (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)
- Methods of diagnosing tau-protein-associated disease (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)
- Pharmaceutical composition (Inventor)
- ANTIBODIES RECOGNISING PHOSPHO-TAU (Inventor)
- Phosphospecific antibodies recognising tau (Inventor)