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Researcher
Frauke Christ
- Disciplines:Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Laboratory medicine
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jan 2004 → 30 Sep 2005
Projects
1 - 10 of 31
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- ORDECA – ORganoid Drug screening for Endometrial CAncerIdentifying novel drugs and biomarkers for treating endometrial cancer using a high-throughput patient-derived organoid drug discovery and screening platformFrom1 Oct 2023 → TodayFunding: IOF - technology validation in lab
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- OrganID: Organ-derived complex 2D/3D cultures in human diseaseFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Investigation of the SARS-CoV-2.From1 Sep 2020 → 31 Aug 2022Funding: Foreign Nonprofit organisations and equivalents
Publications
41 - 50 of 123
- Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75(2015)
Authors: Zeger Debyser, Frauke Christ
Pages: 288 - 94 - HIV-1 IN/Pol recruits LEDGF/p75 into viral particles(2015)
Authors: Belete Ayele Desimmie, Caroline Weydert, Rik Schrijvers, Sofie Vets, Jonas Demeulemeester, Paul Proost, Jan De Rijck, Rik Gijsbers, Frauke Christ, Zeger Debyser
- HIV-1 IN/Pol recruits LEDGF/p75 into viral particles(2015)
Authors: Belete Ayele Desimmie, Caroline Weydert, Rik Schrijvers, Sofie Vets, Jonas Demeulemeester, Paul Proost, Igor Paron, Jan De Rijck, Jan Mast, Norbert Bannert, et al.
Pages: 1 - 15 - Host factors for retroviral integration site selection(2015)
Authors: Zeger Debyser, Frauke Christ, Jan De Rijck, Rik Gijsbers
Pages: 108 - 116 - Cellular cofactors as drug targets(2015)
Authors: Belete Ayele Desimmie, Frauke Christ, Zeger Debyser
Pages: 1 - 7 - Targeting Cellular Cofactors in HIV Therapy(2015)
Authors: Frauke Christ
Pages: 183 - 222Number of pages: 40 - Role of Transportin-SR2 (Transportin-3, TRN-SR2, TNPO3) in HIV replication(2015)
Authors: Frauke Christ, Zeger Debyser
Pages: 1 - 5 - Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors(2015)
Authors: Frauke Christ, Zeger Debyser
Pages: 3208 - 3214 - Cellular cofactors as drug targets(2015)
Authors: Belete Ayele Desimmie, Frauke Christ, Zeger Debyser
Pages: 1 - 7 - Role of Transportin-SR2 (Transportin-3, TRN-SR2, TNPO3) in HIV replication(2015)
Authors: Frauke Christ, Zeger Debyser
Pages: 1 - 5
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)