Researcher
Frauke Christ
- Disciplines:Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Laboratory medicine
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Jan 2004 → 30 Sep 2005
Projects
1 - 10 of 31
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- ORDECA – ORganoid Drug screening for Endometrial CAncerIdentifying novel drugs and biomarkers for treating endometrial cancer using a high-throughput patient-derived organoid drug discovery and screening platformFrom1 Oct 2023 → TodayFunding: IOF - technology validation in lab
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- OrganID: Organ-derived complex 2D/3D cultures in human diseaseFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Investigation of the SARS-CoV-2.From1 Sep 2020 → 31 Aug 2022Funding: Foreign Nonprofit organisations and equivalents
Publications
21 - 30 of 123
- Impact of LEDGIN treatment during virus production on residual HIV-1 transcription(2019)
Authors: Greet Vansant, Irena Zurnic, Dominique Van Looveren, Rik Gijsbers, Frauke Christ, Zeger Debyser
- Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry(2019)
Authors: Frauke Christ, Zeger Debyser
Pages: 398 - 401 - Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection(2019)
Authors: Zeger Debyser, Greet Vansant, Anne Bruggemans, Julie Janssens, Frauke Christ
- Synthesis, Molecular odelling and Biological Studies of 3-hydroxypyrane-4-one and 3-hydroxy-nyridine-4-one Derivatives as HIV-1 Integrase Inhibitors(2019)
Authors: Frauke Christ, Zeger Debyser
Pages: 755 - 770 - HIV nuclear import and chromatin reading as novel drug targets(2018)
Authors: Jolien Blokken, Zeger Debyser, Frauke Christ
- Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation(2018)
Authors: Jan De Rijck, Jonas Demeulemeester, Siska Van Belle, Frauke Christ, Zeger Debyser
Pages: E7053 - E7062 - Inhibitors of the Integrase–Transportin-SR2 interaction block HIV nuclear import(2018)
Authors: Jonas Demeulemeester, Jolien Blokken, Stéphanie De Houwer, Lieve Dirix, Arnaud Marchand, Patrick Chaltin, Frauke Christ, Zeger Debyser
- LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis(2017)
Authors: Sara Elashkar, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Nancy Boeckx, Zeger Debyser, Jan De Rijck
Pages: 95 - 107 - N-terminal half of transportin SR2 interacts with HIV integrase(2017)
Authors: Jolien Blokken, Flore De Wit, Stéphanie De Houwer, Zeger Debyser, Frauke Christ, Sergei Strelkov
Pages: 9699 - 9710 - Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets(2017)
Authors: Jolien Blokken, Jan De Rijck, Frauke Christ, Zeger Debyser
Pages: 25 - 31
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)