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Researcher
Frauke Christ
- Disciplines:Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Laboratory medicine
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Oct 2005 → Today
Projects
1 - 10 of 26
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: BOF - projects, Fund Recuperation Fiscal Exemption
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → TodayFunding: BOF - scientific equipment program
- OrganID: Organ-derived complex 2D/3D cultures in human diseaseFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Investigation of the SARS-CoV-2.From1 Sep 2020 → TodayFunding: Foreign Nonprofit organisations and equivalents
- Strategies against persistent HIV-1 reservoirs(SAPHIR)From1 Jan 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting the chromatin-reader function of LEDGF/p75 for the treatment of Mixed-Lineage-Leukemia (TReaT-MLL)From1 Oct 2018 → 30 Sep 2020Funding: IOF - Industrial Research Fund
- Development of an LEDGF/p75 based strategy for the treatment of MLL-rearranged leukemia.From1 Jan 2018 → 31 Dec 2021Funding: FWO research project
- Single virus imaging of early steps of HIV replicationFrom1 Oct 2017 → 30 Sep 2021Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 119
- Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids(2022)
Authors: Marjolein Ensinck, Senne Cuyx, Lieven Dupont, Frauke Christ, Zeger Debyser, François Vermeulen, Marianne Carlon
Number of pages: 12 - CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Julie Janssens, Rik Gijsbers, Frauke Christ, Zeger Debyser
Number of pages: 22 - Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Ivan Nombela Diaz, Julie Janssens, Frauke Christ, Zeger Debyser
Number of pages: 16 - GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture(2021)
Authors: Anne Bruggemans, Frauke Christ, Zeger Debyser
Number of pages: 17 - LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators(2021)
Authors: Siska Van Belle, Marianne Carlon, Frauke Christ, Zeger Debyser
Pages: 133 - 140Number of pages: 8 - Towards a functional cure of HIV-1: insight in the chromatin landscape of the provirus(2021)
Authors: Julie Janssens, Anne Bruggemans, Frauke Christ, Zeger Debyser
Number of pages: 12 - LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection(2021)
Authors: Zeger Debyser, Anne Bruggemans, Siska Van Belle, Julie Janssens, Frauke Christ
Pages: 97 - 114Number of pages: 18 - Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival(2021)
Authors: Siska Van Belle, Frauke Christ, Zeger Debyser
Number of pages: 18 - Molecular Mechanism of LEDGF/p75 Dimerization(2020)
Authors: Frauke Christ, Zeger Debyser
Pages: 1288 - +Number of pages: 19 - Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration(2020)
Authors: Veerle Lemmens, Susana Neves Rocha, Frauke Christ, Jelle Hendrix, Johan Hofkens, Zeger Debyser
Number of pages: 29