Researcher
Frank Claessens
- Disciplines:Endocrinology, Structural biology, Molecular and cell biology not elsewhere classified, Cancer biology, Urology and nephrology not elsewhere classified
Affiliations
- Laboratory of Molecular Endocrinology (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Molecular Endocrinology (Division)
Member
From1 Oct 2007 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 2000 → 31 Dec 2002
Projects
1 - 10 of 36
- Free steroid hormones in health and disease (FRESH-HD)From23 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Cooperativity between the androgen receptor and forkhead box A1 transcription factorFrom7 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- New therapeutic targets in the dimerization modes that drive androgen receptor functioningFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- New therapeutic targets in the dimerization modes that drive androgen receptor functioningFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Peroxisomes and the Malignant Potential of Prostate Cancer Cells.From17 Jun 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- TISSUE-SPECIFIC MODULATION OF GLUCOCORTICOID EFFECTS BY ANDROGENSFrom26 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Tissue specific modulation of the effects of glucocorticoids by androgens and the androgen receptor: revealing the mechanisms of cross talFrom1 Oct 2020 → TodayFunding: BOF - doctoral mandates
- Classical and non-classical actions of androgens and their receptorFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- The role of androgens in chronic kidney desease: a missing link in the calcification paradox?From1 Aug 2019 → 31 Oct 2023Funding: FWO fellowships
- Structural Biology of the Human Androgen Receptor for next generation drug designFrom12 Mar 2018 → 12 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 222
- A disease-associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer(2022)
Authors: Elien Smeets, Xiao Yin Lee, Christine Helsen, Sarah El Kharraz, Roy Eerlings, Stephanie Humblet-Baron, Arnout Voet, Anne Rochtus, Ann Van Schepdael, Francis de Zegher, et al.
Pages: 2242 - 2253 - N/C interactions are dispensable for normal in vivo functioning of the androgen receptor in male mice(2022)
Authors: Sarah El Kharraz, Vanessa Dubois, Elien Smeets, Roy Eerlings, Dirk Vanderschueren, Christine Helsen, Frank Claessens
- Inactivation of AR or ERα in Extrahypothalamic Neurons Does not Affect Osteogenic Response to Loading in Male Mice(2022)
Authors: Karel David, Vera Maria Johanna Sommers, Leen Antonio, Brigitte Decallonne, Frank Claessens, Dirk Vanderschueren, Vanessa Dubois
- Single-cell transcriptome and chromatin sequencing uncover gene expression and gene regulatory patterns associated with enzalutamide resistance(2022)
Authors: Frank Claessens
- The role of receptor dimerization in androgen action: uncovering its physiological relevance using knockin mouse models(2022)
Authors: Sarah El Kharraz, Frank Claessens, Christine Helsen
- Clinical and preclinical studies of modulators of high-risk prostate cancer with metastatic potential(2022)
Authors: Lisa Moris, Frank Claessens, Steven Joniau
- Intake Patterns of Specific Alcoholic Beverages by Prostate Cancer Status(2022)
Authors: Frank Claessens, Steven Joniau
- Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer(2022)
Authors: Lisa Moris, Bram Boeckx, Diether Lambrechts, Christine Helsen, Stefaan Soenen, Elien Smeets, Roy Eerlings, Sarah El Kharraz, Hendrik Van Poppel, Steven Joniau, et al.
Pages: 527 - 541 - Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score(2022)
Authors: Frank Claessens
Pages: 755 - 761 - Small-molecule profiling for steroid receptor activity using a universal steroid receptor reporter assay(2022)
Authors: Roy Eerlings, Tien Nguyen, Elien Smeets, Lisa Moris, Sarah El Kharraz, Arnout Voet, Wim Dehaen, Frank Claessens, Christine Helsen