Researcher
Erik De Clercq
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2013
Publications
1 - 10 of 469 results
- Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase(2021)
Authors: D Feng, X Zuo, L Jing, C Chen, FA Olotu, H Lin, M Soliman, Erik De Clercq, Christophe Pannecouque, K Lee, et al.
Number of pages: 16 - Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility(2020)
Authors: Zhao Wang, Dongwei Kang, Da Feng, Srinivasulu Cherukupalli, Xiangyi Jiang, Zhipeng Fu, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Number of pages: 17 - Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7(2020)
Authors: Songkai Sun, Boshi Huang, Zhuo Li, Zhao Wang, Lin Sun, Ping Gao, Dongwei Kang, Chin-Ho Chen, Kuo-Hsiung Lee, Dirk Daelemans, et al.
Number of pages: 5 - Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs(2020)
Authors: Dongwei Kang, Yanying Sun, N Arul Murugan, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, et al.
Pages: 2225 - 2234Number of pages: 10 - The impact of single and combined PPAR-alpha and PPAR-gamma activation on the neurological outcomes following cerebral ischemia reperfusion(2020)
Authors: Erik De Clercq
Number of pages: 1 - Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years(2020)
Authors: C Zhuang, Christophe Pannecouque, Erik De Clercq, F Chen
Pages: 961 - 978 - Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1(2020)
Authors: Yang Yang, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Chen
Number of pages: 10 - Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities(2020)
Authors: Lin Sun, Alexej Dick, Megan E Meuser, Tianguang Huang, Waleed A Zalloum, Chin-Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, et al.
Pages: 4790 - 4810Number of pages: 21 - Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties(2020)
Authors: D Kang, D Feng, Y Sun, Z Fang, F Wei, Erik De Clercq, Christophe Pannecouque, X Liu, P Zhan
Pages: 4837 - 4848 - Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles(2020)
Authors: Sheng Han, Yali Sang, Yan Wu, Yuan Tao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Che
Pages: 787 - 801Number of pages: 15