Researcher
Erik De Clercq
- Keywords:Medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2013
Publications
1 - 10 of 467 results
- Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7(2020)Journal: Bioorganic & Medicinal Chemistry LettersISSN: 0960-894XIssue: 16Volume: 30
Authors: Songkai Sun, Boshi Huang, Zhuo Li, Zhao Wang, Lin Sun, Ping Gao, Dongwei Kang, Chin-Ho Chen, Kuo-Hsiung Lee, Dirk Daelemans, et al.
Number of pages: 5 - Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs(2020)Journal: ACS Infectious DiseasesISSN: 2373-8227Issue: 8Volume: 6
Authors: Dongwei Kang, Yanying Sun, N Arul Murugan, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, et al.
Pages: 2225 - 2234Number of pages: 10 - The impact of single and combined PPAR-alpha and PPAR-gamma activation on the neurological outcomes following cerebral ischemia reperfusion(2020)Journal: Life SciencesISSN: 0024-3205Volume: 252
Authors: Erik De Clercq
Number of pages: 1 - Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1(2020)Journal: Bioorganic ChemistryISSN: 0045-2068Volume: 99
Authors: Yang Yang, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Chen
Number of pages: 10 - Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years(2020)Journal: Acta Pharmaceutica Sinica BISSN: 2211-3835Issue: 6Volume: 10
Authors: C Zhuang, Christophe Pannecouque, Erik De Clercq, F Chen
Pages: 961 - 978 - Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties(2020)Journal: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 9Volume: 63
Authors: D Kang, D Feng, Y Sun, Z Fang, F Wei, Erik De Clercq, Christophe Pannecouque, X Liu, P Zhan
Pages: 4837 - 4848 - Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities(2020)Journal: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 9Volume: 63
Authors: Lin Sun, Alexej Dick, Megan E Meuser, Tianguang Huang, Waleed A Zalloum, Chin-Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, et al.
Pages: 4790 - 4810Number of pages: 21 - Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles(2020)Journal: ACS Infectious DiseasesISSN: 2373-8227Issue: 5Volume: 6
Authors: Sheng Han, Yali Sang, Yan Wu, Yuan Tao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Che
Pages: 787 - 801Number of pages: 15 - In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP(2020)Journal: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 193
Authors: Dongwei Kang, Da Feng, Lanlan Jing, Yanying Sun, Fenju Wei, Xiangyi Jiang, Gaochan Wu, Erik De Clercq, Christophe Pannecouque, Peng Zhan, et al.
Number of pages: 13 - Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs(2020)Journal: Acta Pharmaceutica Sinica BISSN: 2211-3835Issue: 5Volume: 10
Authors: Dongwei Kang, Da Feng, Tiziana Ginex, Jinmi Zou, Fenju Wei, Tong Zhao, Boshi Huang, Yanying Sun, Samuel Desta, Erik De Clercq, et al.
Pages: 878 - 894Number of pages: 17