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Researcher
Dominique Schols
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Responsible
From1 Jan 2014 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
21 - 29 of 29
- Biological characterization of novel CXCR4 and CXCR7/ACKR3 receptor inhibitorsFrom1 Oct 2012 → 10 Oct 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- Exploration of carbohydrate-binding agents and (co)receptor inhibitors directed against HIV entry.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Exploration of the role of HIV envelope glycans on virus entry and the antiviral activity of carbohydrate-binding agents (CBAs)From29 Sep 2011 → 30 Sep 2015Funding: FWO fellowships
- Induction of self-protection of CD4+ T cells against HIV-1 infection.From1 Nov 2010 → 31 Oct 2011Funding: BOF - Other initiatives
- Viral infections: molecular insights, targets for intervention and drug developmentFrom1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Mechanistic study on virus entry and replication. A fundamental approach to the development of new and specific antiviral chemotherapeutics.From1 Jan 2010 → 31 Dec 2014Funding: BOF - Concerted Research Project from 1994
- Cellular CD4 receptor inhibitors as a novel anti-HIV therapy.From1 Oct 2009 → 30 Jun 2010Funding: BOF - Other initiatives
- Anti-HIV activity and mode of action of naturally occurring peptides interfering with the viral entry processFrom1 Oct 2009 → 3 Jun 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dengue virus infection of endothelial cells: Pathogenesis and antiviral potential of glycosaminoglycan targetingFrom1 Sep 2009 → 29 Sep 2015Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 370
- Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres.(2024)
Authors: Dominique Schols, Steven De Jonghe
Pages: 107181 - trans-IV restriction: a new configuration for metal bis-cyclam complexes as potent CXCR4 inhibitors.(2024)
Authors: Tom Van Loy, Dominique Schols
Pages: 5616 - 5623 - Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds(2024)
Authors: Dominique Schols
- Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives(2024)
Authors: Dominique Schols
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity(2024)
Authors: Sam Noppen, Mieke Gouwy, Lisa Verhallen, Mirre De Bondt, Dominique Schols, Pedro Elias Marques, Sofie Struyf, Paul Proost
- Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization(2024)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Membrane-permeable tenofovir-di- and monophosphate analogues(2024)
Authors: Dominique Schols
- Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells(2024)
Authors: Libao Liu, Susan Schlenner, Steven De Jonghe, Dominique Schols, Tom Van Loy
- Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities(2023)
Authors: Dominique Schols, Steven De Jonghe
Patents
1 - 6 of 6
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)