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Researcher
Dominique Schols
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Responsible
From1 Jan 2014 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 29
- Validation of CCR8 agonism as therapeutic strategy for treatment of (auto-)inflammationFrom1 Mar 2024 → TodayFunding: IOF - technology validation in lab
- Real-time, label-free analysis of extracellular vesicles and their proteins using surface plasmon resonance technologyFrom29 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The viral G protein-coupled receptor ORF74: Expanding the toolbox to better understand receptor signaling, function and pharmacologyFrom22 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Elucidation of the mechanism of action of novel HTLV-1 inhibitors: a step-by-step approachFrom21 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development and preclinical evaluation of diagnostic and therapeutic radiopharmaceuticals targeting CXCR4From10 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of allosteric intracellular modulators attenuating chemokine receptor CCR5 signallingFrom1 May 2021 → TodayFunding: BOF - doctoral mandates
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → 31 Dec 2022Funding: IOF - technology validation in lab
- Design and synthesis of next-generation C-C chemokine receptor type 5 antagonists.From28 Jul 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Discovery of CCR7 small molecule inhibitors by virtual screening andhit-to-lead optimization.From1 Oct 2019 → 30 Sep 2021Funding: BOF - projects
Publications
21 - 30 of 371
- REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors(2023)
Authors: Katrijn Boon, Dominique Schols, Tom Van Loy
- Spermine and spermidine bind CXCR4 and inhibit CXCR4-but not CCR5-tropic HIV-1 infection(2023)
Authors: Arnaud Boonen, Dominique Schols
- Entry inhibitors for human respiratory virus SARS-CoV-2.(2023)
Authors: Emiel Vanhulle, Kurt Vermeire, Piet Maes, Lieve Naesens, Dominique Schols
- Synthesis and cancer cell cytotoxicity of 2-aryl-4-(4-aryl-2-oxobut-3-en-1-ylidene)-substituted benzothiazepanes(2023)
Authors: Steven De Jonghe, Dominique Schols
Pages: 117 - 123 - Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics(2023)
Authors: Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde
- Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists(2023)
Authors: Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
- Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutants(2023)
Authors: Emiel Vanhulle, Jordi Doijen, Sam Noppen, Dominique Schols, Annelies Stevaert, Kurt Vermeire
- A regioselective step-by-step C60Cl6 functionalization approach affords a novel family of C60Ar5Th′Th′′H fullerene derivatives with promising antiviral properties(2023)
Authors: Dominique Schols
Pages: 3882 - 3885 - Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2(2023)
Authors: Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
- Cell-Based Electrical Impedance Platform to Evaluate Zika Virus Inhibitors in Real Time(2023)
Authors: Merel Oeyen, Dominique Schols
Patents
1 - 6 of 6
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)