Researcher
Dominic De Groote
- Disciplines:Pharmaceutical technology, Drug discovery and development not elsewhere classified
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Jul 2008 → Today - Research Department (Administrative office)
Member
From1 May 2002 → Today - Department of Pathobiology, Pharmacology and Zoological Medicine (Department)
Member
From1 Jan 1996 → 30 Apr 2001
Projects
1 - 10 of 29
- Identification of optimized Aurora Kinase A PROTACs with suitable PK properties for in vivo proof-of-concept studies (OPTIMAPK).From15 Jul 2023 → TodayFunding: IOF - technology concept exploration
- TARgeted Mrna re-engineering for enhanced Antibody and Cellular immunity (TARMAC)From15 Apr 2023 → TodayFunding: IOF - technology concept exploration
- Introducing mRNA vaccination in chicken: first steps towards a commercial mRNA vaccine against a leading viral infection in chickenFrom1 Nov 2022 → TodayFunding: IOF - technology validation in lab
- Validation of a small molecule system for a safer treatment of chronic inflammationFrom15 Jul 2022 → TodayFunding: IOF - technology validation in lab
- The generation of bona fide T cell precursors for cell therapyFrom15 Apr 2022 → TodayFunding: IOF - technology validation in lab
- Extending the Amalus drug discovery program: validation studies for immuno-oncological and fibrosis indications to increase the IP and investment valueFrom15 Oct 2021 → 30 Sep 2023Funding: IOF - technology concept exploration
- IonKey/MSTM system: enhanced U+2018plug and playU+2019 mass spectrometry for ultrasensitive quantification of small molecules in small sample volumes in life sciences, with applications in the development and valorisation of endotoxin-mitigation strategies (feed additives) and anti-inflammatory drugs (pharma) in livestock.From1 Oct 2021 → 30 Sep 2023Funding: IOF - technology validation in lab
- Targeting transcription factor addiction in acute leukemia (TaTFAL)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- STOP_SEPSIS: investigation into a new concept of sepsis, the
greatest unmet medical need of our times.From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- An innovative class of ionizable lipids for use in lipid nanoparticle based RNA therapeutics and vaccinesFrom15 Jul 2021 → 14 Jul 2022Funding: IOF - technology concept exploration
Publications
1 - 5 of 5
- Epithelial-mesenchymal transition (EMT) as a therapeutic target(2022)
Authors: Sven Jonckheere, Jamie Adams, Dominic De Groote, Kyra Campbell, Geert Berx, Steven Goossens
Pages: 157 - 182 - Synthesis of 1-substituted epibatidine analogues and their in vitro and in vivo evaluation as U+03B1U+2084U+03B2U+2082 nicotinic acetylcholine receptor ligands(2014)
Authors: Thomas Heugebaert, Melissa Van Overtveldt, Ann De Blieck, Benjamin Wuyts, Patrick Augustijns, Eugenia Ponce-Gámez, Alicia Rivera, Dominic De Groote, Romain Lefebvre, Patrick Wouters, et al.
Pages: 2226 - 2234 - Genome sequence of Helicobacter suis supports its role in gastric pathology(2011)
Authors: Miet Vermoote, Tom Vandekerckhove, Bram Flahou, Frank Pasmans, Annemieke Smet, Dominic De Groote, Wim Van Criekinge, Richard Ducatelle, Freddy Haesebrouck
- Genome sequence of Helicobacter suis supports its role in gastric pathology(2011)
Authors: Miet Vermoote, Tom Vandekerckhove, Bram Flahou, Frank Pasmans, Annemieke Smet, Dominic De Groote, Wim Van Criekinge, Richard Ducatelle, Freddy Haesebrouck
Number of pages: 1 - Genome sequence of Helicobacter suis supports its role in gastric pathology(2010)
Authors: Miet Vermoote, Tom Vandekerckhove, Bram Flahou, Frank Pasmans, Annemieke Smet, Dominic De Groote, Wim Van Criekinge, Richard Ducatelle, Freddy Haesebrouck
Number of pages: 1