Researcher
Dirk Tourwe
- Research Expertise:
- organische synthese peptide synthese massaspectrometrie HPLC analyse
- Keywords:Chemistry (incl. biochemistry), General and logistic services
- Users of research expertise:
- organische synthese peptide synthese massaspectrometrie HPLC analyse
Affiliations
- Organic Chemistry (Research group)
Member
From31 Dec 1999 → Today - Vriendenkring VUB (Office)
Member
From1 Oct 2012 → Today - Chemistry (Department)
Member
From1 Oct 2012 → 30 Sep 2022 - Chemistry (Department)
Member
From1 Jun 1996 → 30 Sep 2022 - Organic Chemistry (Research group)
Member
From1 Oct 1974 → 30 Sep 1991
Projects
1 - 3 of 3
- TheraVIP: Design of a VPAC1 neureceptor/neoligand couple for cellular therapy of dentritic cells against inflammatory diseasesFrom1 Jun 2008 → 31 May 2011Funding: Brussels Capital Region
- New heterocyclic scaffolds for conformationally constrained peptide- and peptide mimetic design.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
- Development of new peptide conjugates for radiolabeling.From1 Jan 2008 → 31 Dec 2008Funding: FWO research grant KAN
Publications
31 - 40 of 83
- [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase(2013)
Authors: Alexandros Nikolaou, Isabelle Van Den Eynde, Dirk Tourwe, Georges Vauquelin, Géza Tóth, Jayapal Reddy Mallareddy, Marko Poglitsch, Jo A Van Ginderachter, Patrick Vanderheyden
Pages: 93-102 - Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20(2013)
Authors: Patrycja Kleczkowska, Engin Bojnik, Anna Lesniak, Piotr Kosson, Isabelle Van Den Eynde, Sandor Benyhe, Dirk Tourwe, Andrzej W. Lipkowski
Pages: 836-846 - Amino Triazolo Diazepines (Ata) as Constrained Histidine Mimics(2012)
Authors: Koen Buysse, Julien Farard, Alexandros Nikolaou, Daniel Sejer Pedersen, Dirk Tourwe
Pages: 6468-6471 - Variation of the Net Charge, Lipophilicity, and Side Chain Flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution(2012)
Authors: Alexandre Novoa, Sylvia Van Dorpe, Evelien Wynendaele, Mariana Spetea, Nathalie Bracke, Sofie Stalmans, Cecilia Betti, N.n. Chung, C. Lemieux, Johannes Zuegg, et al.
Pages: 9549-9561 - Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP)(2012)
Authors: Heidi Demaegdt, Aneta Lukaszuk, Géza Tóth, E Szemenyei, Dirk Tourwe
Pages: 194-197 - In vivo antinociception of potent mu opioid
agonist tetrapeptide analogues and comparison
with a compact opioid agonist - neurokinin 1
receptor antagonist chimera(2012)
Authors: Karel Jules Guillemyn, Patrycja Kleczkowska, Alexandre Novoa, Bart Vandormael, Isabelle Van Den Eynde, P. Kosson, Muhammad Faheem Asim, P.w. Schiller, Mariana Spetea, A.w. Lipkowski, et al.
- Superpotent [Dmt(1)]Dermorphin Tetrapeptides Containing the 4-Aminotetrahydro-2-benzazepin-3-one Scaffold with Mixed mu/delta Opioid Receptor Agonistic Properties(2011)
Authors: Bart Vandormael, Danai-Dionysia Fourla, Alexandra Gramowski-Voss, P. Kosson, Dieter G. Weiss, Olaf Schroder, A.w. Lipkowski, Zafiroula Georgoussi, Dirk Tourwe
Pages: 7848-7859 - Asymmetric Synthesis and Conformational Analysis by NMR Spectroscopy and MD of Aba- and alpha-MeAba-Containing Dermorphin Analogues(2011)
Authors: Bart Vandormael, Rien De Wachter, José C. Martins, Pieter M. S. Hendrickx, A. Keresztes, Jayapal Reddy Mallareddy, Fanny Toth, Géza Tóth, Dirk Tourwe
Pages: 2035-2047 - Synthesis, Biological Evaluation, and Automated Docking of Constrained Analogues of the Opioid Peptide H-Dmt-D-Ala-Phe-Gly-NH2 Using the 4- or 5-Methyl Substituted 4-Amino-1,2,4,5-tetrahydro-2-benzazepin-3-one Scaffold(2011)
Authors: Rien De Wachter, Chris De Graaf, A. Keresztes, Bart Vandormael, Géza Tóth, Didier Rognan, Dirk Tourwe
Pages: 6538-6547 - PEGylation of Tc-99m-labeled bombesin analogues improves their pharmacokinetic properties(2011)
Authors: S. Daepp, Elisa Garcia-Garayoa, Veronique Maes, Luc Brans, Dirk Tourwe, Muller Christina, R. Schibli
Pages: 997-1009