Researcher
Dirk Tourwe
- Research Expertise:
- organische synthese peptide synthese massaspectrometrie HPLC analyse
- Keywords:Chemistry (incl. biochemistry), General and logistic services
- Disciplines:Other chemical sciences not elsewhere classified
- Users of research expertise:
- organische synthese peptide synthese massaspectrometrie HPLC analyse
Affiliations
- Organic Chemistry (Research group)
Member
From31 Dec 1999 → Today - Vriendenkring VUB (Office)
Member
From1 Oct 2012 → Today - Chemistry (Department)
Member
From1 Oct 2012 → 30 Sep 2022 - Chemistry (Department)
Member
From1 Jun 1996 → 30 Sep 2022 - Organic Chemistry (Research group)
Member
From1 Oct 1974 → 30 Sep 1991
Projects
1 - 3 of 3
- TheraVIP: Design of a VPAC1 neureceptor/neoligand couple for cellular therapy of dentritic cells against inflammatory diseasesFrom1 Jun 2008 → 31 May 2011Funding: Brussels Capital Region
- New heterocyclic scaffolds for conformationally constrained peptide- and peptide mimetic design.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
- Development of new peptide conjugates for radiolabeling.From1 Jan 2008 → 31 Dec 2008Funding: FWO research grant KAN
Publications
1 - 10 of 85
- Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability(2021)
Authors: Dirk Tourwe, Antonis D. Tsiailanis, Nikolaos Parisis, Baydaa Hirmiz, Mark Del Borgo, Marie Isabel Aguilar, Olivier Van der Poorten, Steven Ballet, Robert E. Widdop, Andreas G. Tzakos
- Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors(2021)
Authors: Dirk Tourwe, Frederic Bihel, Frederic Simonin
Pages: 828-870 - Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure †(2020)
Authors: Charlotte Martin, Luis E. Gimenez, Savannah Y. Williams, Yu Jing, Yiran Wu, Charlie Hollanders, Olivier Van der Poorten, S Gonzalez, K Van Holsbeeck, Santo Previti, et al.
Pages: 357-369 - Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies(2020)
Authors: S Gonzalez, Maria Dumitrascuta, Emilie Eiselt, Stevany Louis, Linda Kunze, Annalisa Blasiol, Melanie Vivancos, Santo Previti, Elke Dewolf, Charlotte Martin, et al.
Pages: 12929-12941 - Neuromedin U and Structural Analogs. IF (2019) 3,946(2020)
Authors: An De Prins, Ann Van Eeckhaut, Ilse Smolders, Dirk Tourwe, Steven Ballet
Pages: 6744-6768 - Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia(2019)
Authors: Emilie Eiselt, S Gonzalez, Charlotte Martin, Magali Chartier, Cecilia Betti, Jean-Michel Longpre, Florine Cavelier, Dirk Tourwe, Louis Gendron, Philippe Sarret
Pages: 4535-4544 - Trifluoromethylated Proline Surrogates as Part of "Pro-Pro" Turn-Inducing Templates(2019)
Authors: Charlène Gadais, Samuel Moors, Dieter Buyst, Krisztina Feher, Kristof Van Hecke, Dirk Tourwe, Thierry Brigaud, Charlotte Martin, Julien Pytkowicz, Gregory Chaume
Pages: 2513-2518 - Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists(2018)
Authors: An De Prins, Charlotte Martin, Yannick Van Wanseele, Csaba Tömböly, Dirk Tourwe, Vicky Caveliers, Birgitte Holst, Ann Van Eeckhaut, Mette Marie Rosenkilde, Ilse Smolders, et al.
Pages: 496–501 - Indoloazepinone-Constrained Oligomers as Cell-Penetrating and Blood-Brain-Barrier-Permeating Compounds. IF 2.593(2018)
Authors: Baptiste Legrand, Lubomir L. Vezenkov, Julia Garcia-Pindado, Nadir Bettache, Astrid Knuhtsen, Daniel Sejer Pedersen, Macarena Sanchez-Navarro, Jean Martinez, Meritxell Teixido, Marcel Garcia, et al.
Pages: 696-705 - Development of potent and proteolytically stable human neuromedin U receptor agonists(2018)
Authors: An De Prins, Charlotte Martin, Yannick Van Wanseele, Louise Julie Skov, Csaba Tömböly, Dirk Tourwe, Vicky Caveliers, Ann Van Eeckhaut, Birgitte Holst, Mette Marie Rosenkilde, et al.
Pages: 887-897